WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124881
CAS#: 1161877-58-2
Description: ABX196, a Novel Enhancer of Cancer Immunotherapy, is iNKT Agonist.
Hodoodo Cat#: H124881
Name: ABX-196
CAS#: 1161877-58-2
Chemical Formula: C50H98N2O9
Exact Mass: 870.73
Molecular Weight: 871.340
Elemental Analysis: C, 68.92; H, 11.34; N, 3.22; O, 16.53
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Synonym: ABX-196; ABX 196; ABX196
IUPAC/Chemical Name: N-((2S,3S,4R)-1-(((2S,3R,4S,5R,6R)-6-(acetamidomethyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxyoctadecan-2-yl)tetracosanamide
InChi Key: VITDDUXZOHEQMU-BYSUZVQFSA-N
InChi Code: InChI=1S/C50H98N2O9/c1-4-6-8-10-12-14-16-18-19-20-21-22-23-24-25-26-28-30-32-34-36-38-45(55)52-42(40-60-50-49(59)48(58)47(57)44(61-50)39-51-41(3)53)46(56)43(54)37-35-33-31-29-27-17-15-13-11-9-7-5-2/h42-44,46-50,54,56-59H,4-40H2,1-3H3,(H,51,53)(H,52,55)/t42-,43+,44+,46-,47-,48-,49+,50-/m0/s1
SMILES Code: CCCCCCCCCCCCCCCCCCCCCCCC(N[C@H]([C@@H]([C@@H](CCCCCCCCCCCCCC)O)O)CO[C@H]1O[C@@H]([C@@H]([C@@H]([C@H]1O)O)O)CNC(C)=O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 871.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Tefit JN, Crabé S, Orlandini B, Nell H, Bendelac A, Deng S, Savage PB, Teyton
L, Serra V. Efficacy of ABX196, a new NKT agonist, in prophylactic human
vaccination. Vaccine. 2014 Oct 21;32(46):6138-45. doi:
10.1016/j.vaccine.2014.08.070. Epub 2014 Sep 13. PMID: 25218293; PMCID:
PMC4233108.
2: Scherrer D, Barrett N, Teyton L, Pearce T, Nitcheu J, Pouletty P, Santo J,
Ehrlich HJ. Demonstration of the Antitumor Activity of the iNKT Agonist ABX196,
a Novel Enhancer of Cancer Immunotherapy, in Melanoma and Hepatocarcinoma Mouse
Models. Mol Cancer Ther. 2022 Dec 2;21(12):1788-1797. doi:
10.1158/1535-7163.MCT-22-0183. PMID: 36198025; PMCID: PMC9716246.