CGP-12177 C-11, (S)-

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H124908

CAS#: 135579-76-9

Description: CGP-12177 C-11, (S)- is a radioligand for beta-adrenoreceptors.

Chemical Structure

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CGP-12177 C-11, (S)-
CAS# 135579-76-9
Instruction

Theoretical Analysis

Hodoodo Cat#: H124908
Name: CGP-12177 C-11, (S)-
CAS#: 135579-76-9
Chemical Formula: C1311CH21N3O3
Exact Mass: 278.17
Molecular Weight: 278.340
Elemental Analysis: C, 60.05; H, 7.61; N, 15.10; O, 17.24

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: 0LW22W2PGO; 11c-Cgp 12177; UNII-0LW22W2PGO; (-)-Cgp-12177 C-11; CGP-12177 C-11, (S)-

IUPAC/Chemical Name: (R)-4-(3-(tert-butylamino)-2-hydroxypropoxy)-1,3-dihydro-2H-benzo[d]imidazol-2-one-2-11C

InChi Key: UMQUQWCJKFOUGV-GGPOKGSQSA-N

InChi Code: InChI=1S/C14H21N3O3/c1-14(2,3)15-7-9(18)8-20-11-6-4-5-10-12(11)17-13(19)16-10/h4-6,9,15,18H,7-8H2,1-3H3,(H2,16,17,19)/t9-/m1/s1/i13-1

SMILES Code: CC(C)(C)NC[C@@H](O)COC1=C2N[11C](=O)NC2=CC=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 278.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Leung K. S-4-(3-([11C]Isopropylamino)-2-hydroxypropoxy)-2 >H-benzimidazol-2-one. 2006 Jan 20 [updated 2011 Feb 12]. In: Molecular
Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National
Center for Biotechnology Information (US); 2004–2013. PMID: 20641409.

2: Ueki J, Rhodes CG, Hughes JM, De Silva R, Lefroy DC, Ind PW, Qing F, Brady F,
Luthra SK, Steel CJ, et al. In vivo quantification of pulmonary beta-
adrenoceptor density in humans with (S)-[11C]CGP-12177 and PET. J Appl Physiol
(1985). 1993 Aug;75(2):559-65. doi: 10.1152/jappl.1993.75.2.559. PMID: 7901192.

3: Merlet P, Delforge J, Syrota A, Angevin E, Mazière B, Crouzel C, Valette H,
Loisance D, Castaigne A, Randé JL. Positron emission tomography with 11C
CGP-12177 to assess beta-adrenergic receptor concentration in idiopathic dilated
cardiomyopathy. Circulation. 1993 Apr;87(4):1169-78. doi:
10.1161/01.cir.87.4.1169. PMID: 8096441.

4: Nishijima K, Kuge Y, Seki K, Ohkura K, Morita K, Nakada K, Tamaki N.
Preparation and pharmaceutical evaluation for clinical application of high
specific activity S-(-)[11C]CGP-12177, a radioligand for beta-adrenoreceptors.
Nucl Med Commun. 2004 Aug;25(8):845-9. doi: 10.1097/01.mnm.0000134320.39903.75.
PMID: 15266181.

5: Brady F, Luthra SK, Tochon-Danguy HJ, Steel CJ, Waters SL, Kensett MJ,
Landais P, Shah F, Jaeggi KA, Drake A, et al. Asymmetric synthesis of a
precursor for the automated radiosynthesis of
S-(3'-t-butylamino-2'-hydroxypropoxy)-benzimidazol-2-[11C]one (S-[11C]CGP 12177)
as a preferred radioligand for beta-adrenergic receptors. Int J Rad Appl Instrum
A. 1991;42(7):621-8. doi: 10.1016/0883-2889(91)90032-v. PMID: 1685153.

6: Elsinga PH, van Waarde A, Jaeggi KA, Schreiber G, Heldoorn M, Vaalburg W.
Synthesis and evaluation of (S)-4-(3-(2'-[11C]isopropylamino)-2-hydroxypropoxy)
-2H-benzimidazol -2-one ((S)-[11C]CGP 12388) and
(S)-4-(3-((1'-[18F]-fluoroisopropyl)amino)-2-hydroxypropoxy) -2H-
benzimidazol-2-one ((S)-[18F]fluoro-CGP 12388) for visualization of beta-
adrenoceptors with positron emission tomography. J Med Chem. 1997 Nov
7;40(23):3829-35. doi: 10.1021/jm970267h. PMID: 9371248.