WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124906
CAS#: 1262657-50-0
Description: N-Methyldiaminostilbene C-11 is a novel radiotracer for in vivo microPET imaging of myelination.
Hodoodo Cat#: H124906
Name: N-Methyldiaminostilbene C-11
CAS#: 1262657-50-0
Chemical Formula: C1411CH16N2
Exact Mass: 223.14
Molecular Weight: 223.310
Elemental Analysis: C, 80.23; H, 7.22; N, 12.55
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Synonym: (11C)Medas; N-c-11-Methyldiaminostilbene; N-Methyldiaminostilbene C-11; 98VH0B97M6; N-Methyl-(11C)- diaminostilbene
IUPAC/Chemical Name: (E)-4-(4-aminostyryl)-N-(methyl-11C)aniline
InChi Key: LSXVZFZGGWPTSL-CKRIYKSPSA-N
InChi Code: InChI=1S/C15H16N2/c1-17-15-10-6-13(7-11-15)3-2-12-4-8-14(16)9-5-12/h2-11,17H,16H2,1H3/b3-2+/i1-1
SMILES Code: [11CH3]NC1=CC=C(\C=C\C2=CC=C(N)C=C2)C=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 223.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Auvity S, Tonietto M, Caillé F, Bodini B, Bottlaender M, Tournier N, Kuhnast
B, Stankoff B. Repurposing radiotracers for myelin imaging: a study comparing
18F-florbetaben, 18F-florbetapir, 18F-flutemetamol,11C-MeDAS, and 11C-PiB. Eur J
Nucl Med Mol Imaging. 2020 Feb;47(2):490-501. doi: 10.1007/s00259-019-04516-z.
Epub 2019 Nov 4. PMID: 31686177.
2: de Paula Faria D, de Vries EF, Sijbesma JW, Dierckx RA, Buchpiguel CA, Copray
S. PET imaging of demyelination and remyelination in the cuprizone mouse model
for multiple sclerosis: a comparison between [11C]CIC and [11C]MeDAS.
Neuroimage. 2014 Feb 15;87:395-402. doi: 10.1016/j.neuroimage.2013.10.057. Epub
2013 Nov 2. PMID: 24188813.
3: Faria Dde P, Copray S, Sijbesma JW, Willemsen AT, Buchpiguel CA, Dierckx RA,
de Vries EF. PET imaging of focal demyelination and remyelination in a rat model
of multiple sclerosis: comparison of [11C]MeDAS, [11C]CIC and [11C]PIB. Eur J
Nucl Med Mol Imaging. 2014 May;41(5):995-1003. doi: 10.1007/s00259-013-2682-6.
Epub 2014 Feb 6. PMID: 24499866.
4: Wu C, Zhu J, Baeslack J, Zaremba A, Hecker J, Kraso J, Matthews PM, Miller
RH, Wang Y. Longitudinal positron emission tomography imaging for monitoring
myelin repair in the spinal cord. Ann Neurol. 2013 Nov;74(5):688-98. doi:
10.1002/ana.23965. Epub 2013 Sep 23. PMID: 23818306.
5: Wu C, Wang C, Popescu DC, Zhu W, Somoza EA, Zhu J, Condie AG, Flask CA,
Miller RH, Macklin W, Wang Y. A novel PET marker for in vivo quantification of
myelination. Bioorg Med Chem. 2010 Dec 15;18(24):8592-9. doi:
10.1016/j.bmc.2010.10.018. Epub 2010 Nov 9. PMID: 21071233; PMCID: PMC3044472.