WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124912
CAS#: N/A
Description: Sulfonadyn-47 is a dynamin inhibitor. It inhibits dynamin GTPase activity in a cell-free assay
Hodoodo Cat#: H124912
Name: Sulfonadyn-47
CAS#: N/A
Chemical Formula: C22H23BrN2O2S
Exact Mass: 458.07
Molecular Weight: 459.400
Elemental Analysis: C, 57.52; H, 5.05; Br, 17.39; N, 6.10; O, 6.97; S, 6.98
Synonym: Sulfonadyn-47; Sulfonadyn47; Sulfonadyn 47
IUPAC/Chemical Name: (E)-N-(3-((3-(4-bromophenyl)allyl)amino)propyl)naphthalene-1-sulfonamide
InChi Key: ZYCDTZNHEUVRAI-GQCTYLIASA-N
InChi Code: InChI=1S/C22H23BrN2O2S/c23-20-13-11-18(12-14-20)6-4-15-24-16-5-17-25-28(26,27)22-10-3-8-19-7-1-2-9-21(19)22/h1-4,6-14,24-25H,5,15-17H2/b6-4+
SMILES Code: O=S(C1=C2C=CC=CC2=CC=C1)(NCCCNC/C=C/C3=CC=C(Br)C=C3)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 459.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Odell LR, Jones NC, Chau N, Robertson MJ, Ambrus JI, Deane FM, Young KA, Whiting A, Xue J, Prichard K, Daniel JA, Gorgani NN, O'Brien TJ, Robinson PJ, McCluskey A. The sulfonadyns: a class of aryl sulfonamides inhibiting dynamin I GTPase and clathrin mediated endocytosis are anti-seizure in animal models. RSC Med Chem. 2023 Apr 26;14(8):1492-1511. doi: 10.1039/d2md00371f. PMID: 37593570; PMCID: PMC10429932.