WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H124934


Description: JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei, the causative parasite of African trypanosomiasis. JC-229 is highly toxic to T. brucei cells, while mildly toxic to human cells. JC-229 treatment mimics the effects of TbRPA1 depletion, including DNA replication inhibition and DNA damage accumulation. JC-229 inhibits the activity of TbRPA1, but not the human ortholog.

Chemical Structure


Theoretical Analysis

Hodoodo Cat#: H124934
Name: JC-229
Chemical Formula: C20H14Cl4N2O3S
Exact Mass: 501.95
Molecular Weight: 504.200
Elemental Analysis: C, 47.64; H, 2.80; Cl, 28.12; N, 5.56; O, 9.52; S, 6.36

Price and Availability

Size Price Availability Quantity
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3850 2 Weeks
2g USD 5850 2 Weeks
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Synonym: JC-229; JC 229; JC229

IUPAC/Chemical Name: N-(3,4-dichlorophenyl)-3-(N-(3,4-dichlorophenyl)sulfamoyl)-4-methylbenzamide


InChi Code: InChI=1S/C20H14Cl4N2O3S/c1-11-2-3-12(20(27)25-13-4-6-15(21)17(23)9-13)8-19(11)30(28,29)26-14-5-7-16(22)18(24)10-14/h2-10,26H,1H3,(H,25,27)

SMILES Code: O=C(NC1=CC=C(Cl)C(Cl)=C1)C2=CC=C(C)C(S(=O)(NC3=CC=C(Cl)C(Cl)=C3)=O)=C2

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 504.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Mukherjee A, Hossain Z, Erben E, Ma S, Choi JY, Kim HS. Identification of a small-molecule inhibitor that selectively blocks DNA-binding by Trypanosoma brucei replication protein A1. Nat Commun. 2023 Jul 20;14(1):4390. doi: 10.1038/s41467-023-39839-x. PMID: 37474515; PMCID: PMC10359466.