WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124931
CAS#: 1371564-45-2
Description: LZWL02003 is a neuroprotective agent and derivative of N-salicyloyl tryptamine. LZWL02003 upregulated the expression of Bcl-2 and downregulated the expression of Bax, thus maintaining the homeostasis of Bcl-2/Bax proteins and preventing apoptosis. LZWL02003 also reduced oxidative stress by reducing malondialdehyde and reactive oxygen species levels, increasing the superoxide dismutase activity, and resolving mitochondrial malfunction. LZWL02003 can lower interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and IL-6 levels, which in turn suppress neuroinflammation. LZWL02003 suppressed the phosphorylation activation of NF-κB pathway-related proteins and decreased the nuclear translocation of NF-κB p65 subunits. LZWL02003 is a neuroprotective agent with pleiotropic effects and may be a candidate for treating cerebral I/R injury.
Hodoodo Cat#: H124931
Name: LZWL02003
CAS#: 1371564-45-2
Chemical Formula: C18H18N2O2
Exact Mass: 294.14
Molecular Weight: 294.350
Elemental Analysis: C, 73.45; H, 6.16; N, 9.52; O, 10.87
Synonym: LZWL02003; LZWL-02003; LZWL 02003; p-methyl-N-salicyloyl Tryptamine
IUPAC/Chemical Name: N-(2-(1H-indol-3-yl)ethyl)-2-hydroxy-4-methylbenzamide
InChi Key: IIXQVHOWQHXBKW-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H18N2O2/c1-12-6-7-15(17(21)10-12)18(22)19-9-8-13-11-20-16-5-3-2-4-14(13)16/h2-7,10-11,20-21H,8-9H2,1H3,(H,19,22)
SMILES Code: O=C(C1=CC=C(C)C=C1O)NCCC2=CNC3=CC=CC=C32
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 294.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Su JH, Wu GP, Peng X, Zhao GQ, Peng Y, Zhang HH, Zhao YT, Sun R, Chen ST, Tian Y, Wang Z. Neuroprotective Effects of an N-Salicyloyl Tryptamine Derivative against Cerebral Ischemia/Reperfusion Injury. ACS Chem Neurosci. 2023 Jun 7;14(11):2146-2158. doi: 10.1021/acschemneuro.3c00149. Epub 2023 May 11. PMID: 37170554.
2: Li X, Wang S, Duan S, Long L, Zhuo L, Peng Y, Xiong Y, Li S, Peng X, Yan Y, Wang Z, Jiang W. Exploring the Therapeutic Effects of Multifunctional N-Salicylic Acid Tryptamine Derivative against Parkinson's Disease. ACS Omega. 2023 Jul 28;8(31):28910-28923. doi: 10.1021/acsomega.3c04277. PMID: 37576637; PMCID: PMC10413456.
