WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H124931

CAS#: 1371564-45-2

Description: LZWL02003 is a neuroprotective agent and derivative of N-salicyloyl tryptamine. LZWL02003 upregulated the expression of Bcl-2 and downregulated the expression of Bax, thus maintaining the homeostasis of Bcl-2/Bax proteins and preventing apoptosis. LZWL02003 also reduced oxidative stress by reducing malondialdehyde and reactive oxygen species levels, increasing the superoxide dismutase activity, and resolving mitochondrial malfunction. LZWL02003 can lower interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and IL-6 levels, which in turn suppress neuroinflammation. LZWL02003 suppressed the phosphorylation activation of NF-κB pathway-related proteins and decreased the nuclear translocation of NF-κB p65 subunits. LZWL02003 is a neuroprotective agent with pleiotropic effects and may be a candidate for treating cerebral I/R injury.

Chemical Structure

CAS# 1371564-45-2

Theoretical Analysis

Hodoodo Cat#: H124931
Name: LZWL02003
CAS#: 1371564-45-2
Chemical Formula: C18H18N2O2
Exact Mass: 294.14
Molecular Weight: 294.350
Elemental Analysis: C, 73.45; H, 6.16; N, 9.52; O, 10.87

Price and Availability

Size Price Availability Quantity
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3850 2 Weeks
2g USD 5850 2 Weeks
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Synonym: LZWL02003; LZWL-02003; LZWL 02003; p-methyl-N-salicyloyl Tryptamine

IUPAC/Chemical Name: N-(2-(1H-indol-3-yl)ethyl)-2-hydroxy-4-methylbenzamide


InChi Code: InChI=1S/C18H18N2O2/c1-12-6-7-15(17(21)10-12)18(22)19-9-8-13-11-20-16-5-3-2-4-14(13)16/h2-7,10-11,20-21H,8-9H2,1H3,(H,19,22)


Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 294.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Su JH, Wu GP, Peng X, Zhao GQ, Peng Y, Zhang HH, Zhao YT, Sun R, Chen ST, Tian Y, Wang Z. Neuroprotective Effects of an N-Salicyloyl Tryptamine Derivative against Cerebral Ischemia/Reperfusion Injury. ACS Chem Neurosci. 2023 Jun 7;14(11):2146-2158. doi: 10.1021/acschemneuro.3c00149. Epub 2023 May 11. PMID: 37170554.

2: Li X, Wang S, Duan S, Long L, Zhuo L, Peng Y, Xiong Y, Li S, Peng X, Yan Y, Wang Z, Jiang W. Exploring the Therapeutic Effects of Multifunctional N-Salicylic Acid Tryptamine Derivative against Parkinson's Disease. ACS Omega. 2023 Jul 28;8(31):28910-28923. doi: 10.1021/acsomega.3c04277. PMID: 37576637; PMCID: PMC10413456.