WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124945
CAS#: N/A
Description: BMS-986172 is a highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a L BMS-986172 showed on-target- and mechanism-based pharmacology. Moreover, its favorable pharmacokinetic (PK) profile and the lack of species variability in the glucuronidation potential resulted in a greater confidence level in the projection of a low dose for achieving targeted efficacious exposures in humans. Consistent with these projections.
Hodoodo Cat#: H124945
Name: BMS-986172
CAS#: N/A
Chemical Formula: C24H22F7N7O3
Exact Mass: 589.17
Molecular Weight: 589.470
Elemental Analysis: C, 48.90; H, 3.76; F, 22.56; N, 16.63; O, 8.14
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Synonym: BMS-986172; BMS986172; BMS 986172;
IUPAC/Chemical Name: (S)-4-(1-(cyclopropylmethyl)-1H-pyrazol-3-yl)-6-(2-fluoro-4-(4,4,4-trifluorobutoxy)phenyl)-3-(5-oxo-4,5-dihydro-1H-tetrazol-1-yl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one
InChi Key: VFFPVFKSCNJAMO-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H22F7N7O3/c25-17-10-14(41-9-1-7-23(26,27)28)4-5-16(17)22(24(29,30)31)11-15(18-6-8-37(34-18)12-13-2-3-13)19(20(39)32-22)38-21(40)33-35-36-38/h4-6,8,10,13H,1-3,7,9,11-12H2,(H,32,39)(H,33,36,40)
SMILES Code: FC1=C([C@@]2(C(F)(F)F)NC(C(N3C(NN=N3)=O)=C(C4=NN(CC5CC5)C=C4)C2)=O)C=CC(OCCCC(F)(F)F)=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 589.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
Discovery of 12 (BMS-986172) as a Highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a Low Human Dose for the Treatment of Metabolic Disorders
Wei Meng, Robert Brigance, James Mignone, Lidet Negash, Guohua Zhao, Saleem Ahmad, Wei Wang, Fang Moore, Xiang-Yang Ye, Jung-Hui Sun, Arvind Mathur, Yi-Xin Li, Anthony Azzara, Zhengping Ma, Ching-Hsuen Chu, Mary Jane Cullen, Suzanne Rooney, Susan Harvey, Lisa Kopcho, Lynn Abell, Kevin O’Malley, William Keim, Elizabeth A. Dierks, Shu Chang, Kimberly A. Foster, David Harden, Marta Dabros, Vineet Goti, Claudia De Oliveira, Gopal Krishna, Mary Ann Pelleymounter, Jean Whaley, Jeffrey A. Robl, Dong Cheng, and Pratik Devasthale
Journal of Medicinal Chemistry Article ASAP
DOI: 10.1021/acs.jmedchem.3c01147
