WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124948
CAS#: N/A
Description: Lipid OA2 is an ionizable lipid which can form single component lipid nanoparticles (LNPs) for delivery of RNA.
Hodoodo Cat#: H124948
Name: Lipid OA2
CAS#: N/A
Chemical Formula: C47H91Cl2N3O5
Exact Mass: 847.63
Molecular Weight: 849.160
Elemental Analysis: C, 66.48; H, 10.80; Cl, 8.35; N, 4.95; O, 9.42
Synonym: Lipid OA2; Lipid-OA-2; Lipid-OA2
IUPAC/Chemical Name: di((Z)-octadec-9-en-1-yl) L-lysyl-L-glutamate dihydrochloride
InChi Key: DBWZQQDZKDSHKF-CTLKWHTASA-N
InChi Code: InChI=1S/C47H89N3O5.2ClH/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-35-41-54-45(51)39-38-44(50-46(52)43(49)37-33-34-40-48)47(53)55-42-36-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;;/h17-20,43-44H,3-16,21-42,48-49H2,1-2H3,(H,50,52);2*1H/b19-17-,20-18-;;/t43-,44-;;/m0../s1
SMILES Code: NCCCC[C@H](N)C(N[C@@H](CCC(OCCCCCCCC/C=C\CCCCCCCC)=O)C(OCCCCCCCC/C=C\CCCCCCCC)=O)=O.Cl.Cl
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 849.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Yu Z, Wu M, Huang Y, Wang Y, Chen Y, Long Q, Lin Z, Xue L, Ju C, Zhang C.
Single-component lipid nanoparticles for engineering SOCS1 gene-silenced
dendritic cells to boost tumor immunotherapy. Biomater Sci. 2022 Dec
20;11(1):263-277. doi: 10.1039/d2bm01549h. PMID: 36440740.