WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124969
CAS#: 947767-67-1
Description: Yohimbine C-11 is a PET tracer.
Hodoodo Cat#: H124969
Name: Yohimbine C-11
CAS#: 947767-67-1
Chemical Formula: C2011CH26N2O3
Exact Mass: 353.21
Molecular Weight: 353.450
Elemental Analysis: C, 71.08; H, 7.41; N, 7.93; O, 13.58
This product is not in stock, which may be available by custom synthesis.
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Synonym: 11c-Yohimbine; (11C)Yohimbine; Yohimbine C-11; 7G5I8N2S10; UNII-7G5I8N2S10
IUPAC/Chemical Name: methyl-11C (1R,2S,4aR,13bS,14aS)-2-hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylate
InChi Key: BLGXFZZNTVWLAY-OPQCJPJISA-N
InChi Code: InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1/i1-1
SMILES Code: [11CH3]OC([C@]1([H])[C@@]2([H])C[C@@]3([H])C4=C(C5=CC=CC=C5N4)CCN3C[C@]2([H])CC[C@]1([H])O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 353.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Nahimi A, Jakobsen S, Munk OL, Vang K, Phan JA, Rodell A, Gjedde A. Mapping
α2 adrenoceptors of the human brain with 11C-yohimbine. J Nucl Med. 2015
Mar;56(3):392-8. doi: 10.2967/jnumed.114.145565. Epub 2015 Jan 29. PMID:
25635132.
2: Jakobsen S, Pedersen K, Smith DF, Jensen SB, Munk OL, Cumming P. Detection of
alpha2-adrenergic receptors in brain of living pig with 11C-yohimbine. J Nucl
Med. 2006 Dec;47(12):2008-15. PMID: 17138744.
3: Landau AM, Doudet DJ, Jakobsen S. Amphetamine challenge decreases yohimbine
binding to α2 adrenoceptors in Landrace pig brain. Psychopharmacology (Berl).
2012 Jul;222(1):155-63. doi: 10.1007/s00213-011-2632-6. Epub 2012 Jan 7. PMID:
22227612.
4: Laurencin C, Lancelot S, Merida I, Costes N, Redouté J, Le Bars D, Boulinguez
P, Ballanger B. Distribution of α2-Adrenergic Receptors in the Living
Human Brain Using [11C]yohimbine PET. Biomolecules. 2023 May
15;13(5):843. doi: 10.3390/biom13050843. PMID: 37238713; PMCID: PMC10216046.
5: Landau AM, Jakobsen S, Thomsen MB, Alstrup AKO, Orlowski D, Jacobsen J,
Wegener G, Mørk A, Sørensen JCH, Doudet DJ. Combined In Vivo Microdialysis and
PET Studies to Validate [11C]Yohimbine Binding as a Marker of
Noradrenaline Release. Biomolecules. 2023 Apr 14;13(4):674. doi:
10.3390/biom13040674. PMID: 37189421; PMCID: PMC10136072.
