FD2157

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H124993

CAS#: N/A

Description: FD-2157 is a photosensitive PI3K inhibitor. FD2157 exhibited remarkably enhanced anticancer activity in inhibition of PI3K pathway against melanoma cell lines upon light irradiation (4 min). Hence, this photosensitive PI3K inhibitor FD2157 may represent a valuable tool compound for studying the PI3K pathway and further optimization toward light-triggered cancer treatment.

Chemical Structure

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FD2157
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H124993
Name: FD2157
CAS#: N/A
Chemical Formula: C27H21ClN6O8S
Exact Mass: 624.08
Molecular Weight: 625.010
Elemental Analysis: C, 51.89; H, 3.39; Cl, 5.67; N, 13.45; O, 20.48; S, 5.13

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: FD2157; FD 2157; FD-2157

IUPAC/Chemical Name: 4,5-dimethoxy-2-nitrobenzyl 5-(6-chloro-5-(phenylsulfonamido)pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridine-1-carboxylate

InChi Key: CNACGENUHFPUCA-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H21ClN6O8S/c1-40-23-10-19(22(34(36)37)11-24(23)41-2)15-42-27(35)33-26-18(14-31-33)8-16(13-30-26)17-9-21(25(28)29-12-17)32-43(38,39)20-6-4-3-5-7-20/h3-14,32H,15H2,1-2H3

SMILES Code: O=S(C1=CC=CC=C1)(NC2=CC(C3=CN=C(N(C(OCC4=CC(OC)=C(OC)C=C4[N+]([O-])=O)=O)N=C5)C5=C3)=CN=C2Cl)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 625.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Yang C, Gong Y, Deng M, Ling Y, Wang J, Zhou Y. Discovery of a photosensitizing PI3K inhibitor for tumor therapy: Design, synthesis and in vitro biological evaluation. Bioorg Med Chem Lett. 2023 Oct 1;94:129459. doi: 10.1016/j.bmcl.2023.129459. Epub 2023 Aug 25. PMID: 37634762.