DJ4
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Hodoodo CAT#: H125048

CAS#: N/A

Description: DJ4 (EX-A7863) is a potent, selective ATP-competitive inhibitor of ROCK1/2 and MRCKα/β.

Chemical Structure

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DJ4
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H125048
Name: DJ4
CAS#: N/A
Chemical Formula: C19H18N4OS
Exact Mass: 350.12
Molecular Weight: 350.440
Elemental Analysis: C, 65.12; H, 5.18; N, 15.99; O, 4.57; S, 9.15

Price and Availability

Size Price Availability Quantity
50mg USD 650 2 Weeks
100mg USD 950 2 Weeks
200mg USD 1450 2 Weeks
500mg USD 2950 2 Weeks
1g USD 4250 2 Weeks
2g USD 6850 2 Weeks
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Synonym: DJ4; D-J4; D J4; EX-A7863; EXA7863; EX A7863; NSC781419; NSC781773; NSC-781419

IUPAC/Chemical Name: (2E,5Z)-5-((3a,7a-dihydro-1H-pyrrolo[2,3-b]pyridin-3-yl)methylene)-2-(phenethylimino)thiazolidin-4-one

InChi Key: LPLHRXWGAXZZJU-WJDWOHSUSA-N

InChi Code: InChI=1S/C19H18N4OS/c24-18-16(11-14-12-22-17-15(14)7-4-9-20-17)25-19(23-18)21-10-8-13-5-2-1-3-6-13/h1-7,9,11-12,15,17,22H,8,10H2,(H,21,23,24)/b16-11-

SMILES Code: O=C(/C(S/1)=C/C2=CNC3N=CC=CC23)NC1=N/CCC4=CC=CC=C4

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 350.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Golla U, Ehudin MA, Annageldiyev C, Zeng Z, Bastihalli Tukaramrao D, Tarren
A, Date AA, Elcheva I, Berg A, Amin S, Loughran TP Jr, Kester M, Desai D, Dovat
S, Claxton D, Sharma A. DJ4 Targets the Rho-Associated Protein Kinase Pathway
and Attenuates Disease Progression in Preclinical Murine Models of Acute Myeloid
Leukemia. Cancers (Basel). 2021 Sep 29;13(19):4889. doi:
10.3390/cancers13194889. PMID: 34638385; PMCID: PMC8508452.

2: Abdul KM, Terada K, Gotoh T, Hafizur RM, Mori M. Characterization and
functional analysis of a heart-enriched DnaJ/ Hsp40 homolog dj4/DjA4. Cell
Stress Chaperones. 2002 Apr;7(2):156-66. doi:
10.1379/1466-1268(2002)007<0156:cafaoa>2.0.co;2. PMID: 12380683; PMCID:
PMC514813.

3: Kale VP, Hengst JA, Sharma AK, Golla U, Dovat S, Amin SG, Yun JK, Desai DH.
Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective
Inhibitor of ROCK and MRCK Kinases. Pharmaceuticals (Basel). 2023 Jul
26;16(8):1060. doi: 10.3390/ph16081060. PMID: 37630974; PMCID: PMC10458458.