WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H125021
CAS#: 183376-09-2
Description: Glutamine 5-C-11 is use for metabolic imaging of tumors.
Hodoodo Cat#: H125021
Name: Glutamine 5-C-11
CAS#: 183376-09-2
Chemical Formula: C411CH10N2O3
Exact Mass: 145.08
Molecular Weight: 145.150
Elemental Analysis: C, 40.69; H, 6.94; N, 19.30; O, 33.07
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: 11c-Glutamine; Glutamine C-11; (11C)-Glutamine; Glutamine 5-C-11; L-Glutamine-5-11c
IUPAC/Chemical Name: L-glutamine-5-11C
InChi Key: ZDXPYRJPNDTMRX-COGNOSNSSA-N
InChi Code: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1/i4-1
SMILES Code: N[C@@H](CC[11C](N)=O)C(O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 145.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Wu F, Orlefors H, Bergström M, Antoni G, Omura H, Eriksson B, Watanabe Y,
Långström B. Uptake of 14C- and 11C-labeled glutamate, glutamine and aspartate
in vitro and in vivo. Anticancer Res. 2000 Jan-Feb;20(1A):251-6. PMID: 10769663.
2: Qu W, Oya S, Lieberman BP, Ploessl K, Wang L, Wise DR, Divgi CR, Chodosh LA,
Thompson CB, Kung HF. Preparation and characterization of L-[5-11C]-glutamine
for metabolic imaging of tumors. J Nucl Med. 2012 Jan;53(1):98-105. doi:
10.2967/jnumed.111.093831. Epub 2011 Dec 15. Erratum in: J Nucl Med. 2012
Apr;53(4):646. Chodosh, Lewis P [corrected to Chodosh, Lewis A]. PMID: 22173839.
3: Gleede T, Riehl B, Shea C, Kersting L, Cankaya AS, Alexoff D, Schueller M,
Fowler JS, Qu W. Investigation of SN2 [11C]cyanation for base-sensitive
substrates: an improved radiosynthesis of L-[5-11C]-glutamine. Amino Acids. 2015
Mar;47(3):525-33. doi: 10.1007/s00726-014-1883-z. Epub 2014 Dec 10. PMID:
25488428.
4: Cohen AS, Grudzinski J, Smith GT, Peterson TE, Whisenant JG, Hickman TL,
Ciombor KK, Cardin D, Eng C, Goff LW, Das S, Coffey RJ, Berlin JD, Manning HC.
First-in-Human PET Imaging and Estimated Radiation Dosimetry of
l-[5-11C]-Glutamine in Patients with Metastatic Colorectal Cancer. J
Nucl Med. 2022 Jan;63(1):36-43. doi: 10.2967/jnumed.120.261594. Epub 2021 Apr
30. PMID: 33931465; PMCID: PMC8717201.
