WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H125040
CAS#: N/A
Description: HUP-55 is an inhibitor of prolyl endopeptidase.
Hodoodo Cat#: H125040
Name: HUP-55
CAS#: N/A
Chemical Formula: C18H21N3O
Exact Mass: 295.17
Molecular Weight: 295.390
Elemental Analysis: C, 73.19; H, 7.17; N, 14.23; O, 5.42
Synonym: HUP-55; HUP55; HUP 55
IUPAC/Chemical Name: (S)-1-(4-methyl-2-(3-phenylpropyl)oxazol-5-yl)pyrrolidine-2-carbonitrile
InChi Key: FEEUIAMWBWZZNX-INIZCTEOSA-N
InChi Code: InChI=1S/C18H21N3O/c1-14-18(21-12-6-10-16(21)13-19)22-17(20-14)11-5-9-15-7-3-2-4-8-15/h2-4,7-8,16H,5-6,9-12H2,1H3/t16-/m0/s1
SMILES Code: CC1=C(N2[C@H](C#N)CCC2)OC(CCCC3=CC=CC=C3)=N1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 295.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Kilpeläinen TP, Pätsi HT, Svarcbahs R, Julku UH, Eteläinen TS, Cui H, Auno S, Sipari N, Norrbacka S, Leino TO, Jäntti M, Myöhänen TT, Wallén EAA. Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α-Synuclein Mouse Models of Parkinson's Disease. J Med Chem. 2023 Jun 8;66(11):7475-7496. doi: 10.1021/acs.jmedchem.3c00235. Epub 2023 May 29. PMID: 37248563; PMCID: PMC10258805.