WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H125020
CAS#: N/A
Description: NODAGA-RGD GALLIUM GA-68 is used for PET imaging.
Hodoodo Cat#: H125020
Name: NODAGA-RGD GALLIUM GA-68
CAS#: N/A
Chemical Formula: C42H6168GaN12O14
Exact Mass: 1,025.37
Molecular Weight: 1,025.950
Elemental Analysis: C, 49.17; H, 5.99; Ga, 6.62; N, 16.38; O, 21.83
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Synonym: 1SG7VTQ3VS; (68GA)NODAGA-RGD; NODAGA-RGD GALLIUM GA-68
IUPAC/Chemical Name: gallium-68Ga 2,2'-(7-(4-((4-((2S,5S,11S,14R)-14-benzyl-11-(carboxymethyl)-5-(3-guanidinopropyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)butyl)amino)-1-carboxylato-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetate
InChi Key: SQBMZUMBUVDIIO-KCJYAIHDSA-K
InChi Code: InChI=1S/C42H64N12O14.Ga/c43-42(44)46-14-6-10-27-37(63)47-23-33(56)48-30(22-34(57)58)40(66)51-29(21-26-7-2-1-3-8-26)39(65)50-28(38(64)49-27)9-4-5-13-45-32(55)12-11-31(41(67)68)54-19-17-52(24-35(59)60)15-16-53(18-20-54)25-36(61)62;/h1-3,7-8,27-31H,4-6,9-25H2,(H,45,55)(H,47,63)(H,48,56)(H,49,64)(H,50,65)(H,51,66)(H,57,58)(H,59,60)(H,61,62)(H,67,68)(H4,43,44,46);/q;+3/p-3/t27-,28-,29+,30-,31?;/m0./s1/i;1-2
SMILES Code: [68Ga+3].NC(=N)NCCC[C@@H]1NC(=O)[C@H](CCCCNC(=O)CCC(N2CCN(CC([O-])=O)CCN(CC([O-])=O)CC2)C([O-])=O)NC(=O)[C@@H](CC3=CC=CC=C3)NC(=O)[C@H](CC(O)=O)NC(=O)CNC1=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 1,025.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Vatsa R, Shukla J, Kumar S, Chakraboarty S, Dash A, Singh G, Mittal BR.
Effect of Macro-Cyclic Bifunctional Chelators DOTA and NODAGA on Radiolabeling
and In Vivo Biodistribution of Ga-68 Cyclic RGD Dimer. Cancer Biother
Radiopharm. 2019 Sep;34(7):427-435. doi: 10.1089/cbr.2019.2811. Epub 2019 May
21. PMID: 31112044.
2: Zhai C, Franssen GM, Petrik M, Laverman P, Summer D, Rangger C, Haubner R,
Haas H, Decristoforo C. Comparison of Ga-68-Labeled Fusarinine C-Based
Multivalent RGD Conjugates and [(68)Ga]NODAGA-RGD-In Vivo Imaging Studies in
Human Xenograft Tumors. Mol Imaging Biol. 2016 Oct;18(5):758-67. doi:
10.1007/s11307-016-0931-3. PMID: 26905697; PMCID: PMC5010584.
3: Zhai C, Summer D, Rangger C, Haas H, Haubner R, Decristoforo C. Fusarinine C,
a novel siderophore-based bifunctional chelator for radiolabeling with
Gallium-68. J Labelled Comp Radiopharm. 2015 May 15;58(5):209-14. doi:
10.1002/jlcr.3286. Epub 2015 Apr 15. PMID: 25874571; PMCID: PMC4682187.
