WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H328304
CAS#: 17289-49-5
Description: Tetridamine, also known as POLI-67, is an analgesic and anti-inflammatory drug used to treat vaginitis.
Hodoodo Cat#: H328304
Name: Tetridamine
CAS#: 17289-49-5
Chemical Formula: C9H15N3
Exact Mass: 165.13
Molecular Weight: 165.240
Elemental Analysis: C, 65.42; H, 9.15; N, 25.43
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Synonym: Tetridamine; POLI-67; POLI 67; POLI67
IUPAC/Chemical Name: N,2-dimethyl-4,5,6,7-tetrahydro-2H-indazol-3-amine
InChi Key: NKDJNEGDJVXHKM-UHFFFAOYSA-N
InChi Code: InChI=1S/C9H15N3/c1-10-9-7-5-3-4-6-8(7)11-12(9)2/h10H,3-6H2,1-2H3
SMILES Code: CNC1=C2CCCCC2=NN1C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 165.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Manzardo S, Girardello R, Pinzetta A, Coppi G, De Aloysio D. Activity and tolerability of tetridamine vaginal lavage in rats and women. Boll Chim Farm. 1992 Mar;131(3):113-6. PubMed PMID: 1418890.
2: Ballesterosé S, Ramón MF, Martínez-Arrieta R. Oral tetridamine exposures. Clin Toxicol (Phila). 2009 Feb;47(2):150-2. doi: 10.1080/15563650801938688. PubMed PMID: 18608303.
3: Pugliares S, Jacobellis M. [Tetridamine in the therapy of bacterial vaginosis]. Minerva Ginecol. 1991 May;43(5):245-51. Review. Italian. PubMed PMID: 1881569.
4: Massaroli G, Cellari C, Coerezza M, Scuri R. [Absorption, metabolism and excretion of 2-methyl-3-methylamino-4,5,6,7-tetrahydroindazole (tetridamine) in the rat]. Boll Chim Farm. 1972 Nov;111(11):649-57. Italian. PubMed PMID: 4655669.