WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H326925
CAS#: 150756-35-7 (free base)
Description: Efletirizine, also known as Ucb-28754, is histamine H1 receptor antagonist potentially for the treatment of allergic rhinitis.
Hodoodo Cat#: H326925
Name: Efletirizine
CAS#: 150756-35-7 (free base)
Chemical Formula: C21H24F2N2O3
Exact Mass: 390.18
Molecular Weight: 390.431
Elemental Analysis: C, 64.60; H, 6.20; F, 9.73; N, 7.18; O, 12.29
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Related CAS #: 150756-35-7 (free base) 225367-66-8 (dihydrochloride)
Synonym: UCB-28754; UCB28754; UCB 28754; Efletirizine
IUPAC/Chemical Name: (2-(4-(Bis(p-fluorophenyl)methyl)-1-piperazinyl)ethoxy)acetic acid
InChi Key: BAWMMJAUVBLLEE-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H24F2N2O3/c22-18-5-1-16(2-6-18)21(17-3-7-19(23)8-4-17)25-11-9-24(10-12-25)13-14-28-15-20(26)27/h1-8,21H,9-15H2,(H,26,27)
SMILES Code: O=C(O)COCCN1CCN(C(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Related CAS# CAS#150756-35-7 (free) CAS#225367-66-8 (dihydrochloride salt)
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 390.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Lewis TA, Young MA, Arrington MP, Bayless L, Cai X, Collart P, Eckman JB,
Ellis JL, Ene DG, Libertine L, Nicolas JM, Scannell RT, Wels BF, Wenberg K, Wypij
DM. Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory
activity. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5591-4. PubMed PMID: 15482930.
2: Salmun LM. Antihistamines in late-phase clinical development for allergic
disease. Expert Opin Investig Drugs. 2002 Feb;11(2):259-73. Review. PubMed PMID:
11829715.
3: Coe RA, DeCesare LS, Lee JW. Quantitation of efletirizine in human plasma and
urine using automated solid-phase extraction and column-switching
high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1999 Jul
9;730(2):239-47. PubMed PMID: 10448959.
