WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H329017
CAS#: 25523-97-1 (free base)
Description: Dexchlorpheniramine, also known as Polaramine, is a histamine receptor antagonist used to treat urticaria, allergic rhinitis, allergic conjunctivitis and pruritus.
Hodoodo Cat#: H329017
Name: Dexchlorpheniramine free base
CAS#: 25523-97-1 (free base)
Chemical Formula: C16H19ClN2
Exact Mass: 274.12
Molecular Weight: 274.790
Elemental Analysis: C, 69.94; H, 6.97; Cl, 12.90; N, 10.19
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Related CAS #: 2438-32-6 (maleate) 25523-97-1 (free base)
Synonym: Dexchlorpheniramine Maleate; Polaramine; Mylaramine;
IUPAC/Chemical Name: 3-(4-chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine
InChi Key: SOYKEARSMXGVTM-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
SMILES Code: CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2
Appearance: White to off-white crystalline powder.
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Related CAS# 2438-32-6 (Dexchlorpheniramine Maleate) 25523-97-1 (Dexchlorpheniramine)
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The following data is based on the product molecular weight 274.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Alabazi MY, Elzein H. An approach to formulating an oral floating drug delivery system for dexchlorpheniramine maleate using factorial design. Pharmazie. 2012 Jul;67(7):611-7. PubMed PMID: 22888518.
2: Ortíz San Román L, Sanavia Morán E, Campos Domínguez M, Peinador García MM. [Anticholinergic syndrome due to dexchlorpheniramine as a cause of urinary retention]. An Pediatr (Barc). 2013 Dec;79(6):400-1. doi: 10.1016/j.anpedi.2013.02.014. Epub 2013 May 13. Spanish. PubMed PMID: 23680058.
3: Van Eeckhaut A, Detaevernier MR, Michotte Y. Development of a validated capillary electrophoresis method for enantiomeric purity testing of dexchlorpheniramine maleate. J Chromatogr A. 2002 Jun 7;958(1-2):291-7. PubMed PMID: 12134827.
4: Gutkowski A, Del Carpio J, Gelinas B, Schulz J, Turenne Y. Comparative study of the efficacy, tolerance and side-effects of dexchlorpheniramine maleate 6 mg b.i.d. with terfenadine 60 mg b.i.d. J Int Med Res. 1985;13(5):284-8. PubMed PMID: 3932106.
5: Munch EP, Søborg M, Nørreslet TT, Mygind N. A comparative study of dexchlorpheniramine maleate sustained release tablets and budesonide nasal spray in seasonal allergic rhinitis. Allergy. 1983 Oct;38(7):517-24. PubMed PMID: 6139040.
6: Viana NS Jr, Moreira-Campos LM, Vianna-Soares CD. Derivative ultraviolet spectrophotometric determination of dexchlorpheniramine maleate in tablets in presence of coloring agents. Farmaco. 2005 Nov-Dec;60(11-12):900-5. Epub 2005 Oct 13. PubMed PMID: 16226263.
7: Wandalsen GF, Miranda C, Ensina LF, Sano F, Amazonas RB, Silva JM, Solé D. Association between desloratadine and prednisolone in the treatment of children with acute symptoms of allergic rhinitis: a double-blind, randomized and controlled clinical trial. Braz J Otorhinolaryngol. 2016 Sep 13. pii: S1808-8694(16)30173-2. doi: 10.1016/j.bjorl.2016.08.009. [Epub ahead of print] PubMed PMID: 27670203.
8: Alfonso Zerquera HM, Bermudez Benitez E, De Armas Leyva R. Sustained release of drugs by inclusion in plastic matrices. I. Dexchlorpheniramine maleate. J Pharm Belg. 1983 Nov-Dec;38(6):315-9. PubMed PMID: 6674474.
9: Halpern BN, Hazard J, Klotz A, Ky NT. [Advantage of adding an injectable solution of dexchlorpheniramine maleate to allergen extracts in specific desensitization]. Rev Fr Allergol. 1965 Nov;5(4):241-3. French. PubMed PMID: 5854652.
10: Jacob RS, Santos LV, de Souza AF, Lange LC. A toxicity assessment of 30 pharmaceuticals using Aliivibrio fischeri: a comparison of the acute effects of different formulations. Environ Technol. 2016 Nov;37(21):2760-7. doi: 10.1080/09593330.2016.1164249. Epub 2016 Apr 4. PubMed PMID: 27020342.
11: Müller FO, Botha JJ, van Dyk M, Luus HG, Groenewoud G. Attenuation of cutaneous reactivity to histamine by cetirizine and dexchlorpheniramine. Eur J Clin Pharmacol. 1988;35(3):319-21. PubMed PMID: 2972549.
12: Moreno RA, Oliveira-Silva D, Sverdloff CE, Borges BC, Rebelo Galvinas PA, Astigarraga RB, Borges NC. Determination of chlorpheniramine in human plasma by HPLC-ESI-MS/MS: application to a dexchlorpheniramine comparative bioavailability study. Biomed Chromatogr. 2010 Jul;24(7):774-81. doi: 10.1002/bmc.1362. PubMed PMID: 19924675.
13: Theunissen EL, Vermeeren A, Ramaekers JG. Repeated-dose effects of mequitazine, cetirizine and dexchlorpheniramine on driving and psychomotor performance. Br J Clin Pharmacol. 2006 Jan;61(1):79-86. PubMed PMID: 16390354; PubMed Central PMCID: PMC1884990.
14: Johansen LV, Bjerrum P, Illum P. Treatment of seasonal allergic rhinitis--a double blind, group comparative study of terfenadine and dexchlorpheniramine. Rhinology. 1987 Mar;25(1):35-40. PubMed PMID: 2883715.
15: Pastorello EA, Ortolani C, Gerosa S, Pravettoni V, Codecasa LR, Fugazza A, Zanussi C. Antihistaminic treatment of allergic rhinitis: a double-blind study with terfenadine versus dexchlorpheniramine. Pharmatherapeutica. 1987;5(2):69-75. PubMed PMID: 2889217.
