WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526900
CAS#: 179258-62-9 (HCl)
Description: SB-237376 is a calcium and potassium channel antagonist potentially for the treatment of arrhythmia.
Hodoodo Cat#: H526900
Name: SB-237376 HCl
CAS#: 179258-62-9 (HCl)
Chemical Formula: C20H26ClN3O5
Exact Mass: 0.00
Molecular Weight: 423.894
Elemental Analysis: C, 56.67; H, 6.18; Cl, 8.36; N, 9.91; O, 18.87
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Synonym: SB-237376 HCl; SB-237376 hydrochloride; SB-237376; SB 237376; SB237376.
IUPAC/Chemical Name: N-(3-((2-(3,4-Dimethoxyphenyl)ethyl)amino)propyl)-4-nitrobenzamide hydrochloride
InChi Key: RJIWGNBRTQFKBW-NRFANRHFSA-N
InChi Code: InChI=1S/C27H24N2O4/c1-2-21(18-11-5-3-6-12-18)29-27(32)24-20-15-9-10-16-22(20)28-25(19-13-7-4-8-14-19)26(24)33-17-23(30)31/h3-16,21H,2,17H2,1H3,(H,29,32)(H,30,31)/t21-/m0/s1
SMILES Code: O=C(NCCCNCCC1=CC=C(OC)C(OC)=C1)C2=CC=C([N+]([O-])=O)C=C2.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Related CAS# 179258-62-9 (SB-237376 hydrochloride) 179258-59-4 (SB-237376 Free)
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 423.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Xu X, Yan GX, Wu Y, Liu T, Kowey PR. Electrophysiologic effects of SB-237376:
a new antiarrhythmic compound with dual potassium and calcium channel blocking
action. J Cardiovasc Pharmacol. 2003 Mar;41(3):414-21. PubMed PMID: 12605020.