SAR-405
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Hodoodo CAT#: H406844

CAS#: 1523406-39-4

Description: SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells.

Chemical Structure

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SAR-405
CAS# 1523406-39-4
Instruction

Theoretical Analysis

Hodoodo Cat#: H406844
Name: SAR-405
CAS#: 1523406-39-4
Chemical Formula: C19H21ClF3N5O2
Exact Mass: 443.13
Molecular Weight: 443.855
Elemental Analysis: C, 51.42; H, 4.77; Cl, 7.99; F, 12.84; N, 15.78; O, 7.21

Price and Availability

Size Price Availability Quantity
5mg USD 285 2 Weeks
10mg USD 450 2 Weeks
25mg USD 750 2 Weeks
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Synonym: SAR-405; SAR 405; SAR405.

IUPAC/Chemical Name: (S)-9-((5-chloropyridin-3-yl)methyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one

InChi Key: SPDQRCUBFSRAFI-DOMZBBRYSA-N

InChi Code: InChI=1S/C19H21ClF3N5O2/c1-12-11-30-5-4-26(12)16-7-17(29)27-3-2-15(19(21,22)23)28(18(27)25-16)10-13-6-14(20)9-24-8-13/h6-9,12,15H,2-5,10-11H2,1H3/t12-,15+/m1/s1

SMILES Code: O=C1C=C(N2[C@H](C)COCC2)N=C3N(CC4=CC(Cl)=CN=C4)[C@H](C(F)(F)F)CCN31

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 443.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Pasquier B. SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and
synergizes with MTOR inhibition in tumor cells. Autophagy. 2015 Apr
3;11(4):725-6. doi: 10.1080/15548627.2015.1033601. PubMed PMID: 25905679; PubMed
Central PMCID: PMC4502822.


2: Marsh T, Debnath J. Ironing out VPS34 inhibition. Nat Cell Biol. 2015
Jan;17(1):1-3. PubMed PMID: 25679028.


3: Ronan B, Flamand O, Vescovi L, Dureuil C, Durand L, Fassy F, Bachelot MF,
Lamberton A, Mathieu M, Bertrand T, Marquette JP, El-Ahmad Y, Filoche-Romme B,
Schio L, Garcia-Echeverria C, Goulaouic H, Pasquier B. A highly potent and
selective Vps34 inhibitor alters vesicle trafficking and autophagy. Nat Chem
Biol. 2014 Dec;10(12):1013-9. doi: 10.1038/nchembio.1681. Epub 2014 Oct 19.
PubMed PMID: 25326666.