WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526912
CAS#: 11676-78-9 (HCl)
Description: TN-871 is a calcium and potassium channel antagonist potentially for the treatment of cerebrovascular. TN-871 modulates transmitter release from preganglionic nerve terminals without changing the postsynaptic sensitivity of the ganglion cells to ACh.
Hodoodo Cat#: H526912
Name: TN-871 HCl
CAS#: 11676-78-9 (HCl)
Chemical Formula: C19H28Cl2N2O2
Exact Mass: 314.20
Molecular Weight: 387.345
Elemental Analysis: C, 58.92; H, 7.29; Cl, 18.30; N, 7.23; O, 8.26
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Synonym: TN-871; TN 871; TN871; TN-871 dihydrochloride.
IUPAC/Chemical Name: 1-(6-butyl-5H-indeno[5,6-d][1,3]dioxol-5-yl)-4-methylpiperazine dihydrochloride
InChi Key:
InChi Code:
SMILES Code: CN1CCN(C2C(CCCC)=CC3=C2C=C4C(OCO4)=C3)CC1.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Related CAS# 118848-33-2 (TN-871) 111676-78-9 TN-871 dihyrochloride)
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 387.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Katayama Y, Morita K, Hirai K. Concentration-dependent actions of a new indene
derivative, TN-871, in the enteric nervous system. Eur J Pharmacol. 1998 Jan
26;342(2-3):167-75. PubMed PMID: 9548382.
2: Shen YL, Hirai K, Katayama Y. Effects of an indene-derivative, TN-871, on
synaptic transmission in a sympathetic ganglion: presynaptic actions on
neurotransmitter release. Bull Tokyo Med Dent Univ. 1995 Mar;42(1):19-29. PubMed
PMID: 7895315.