WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H328034
CAS#: 143-07-7
Description: Lauric acid also known as Dodecanoic Acid and GT-08, is a proton pump inhibitor potentially for the treatment of helicobacter pylori infections. In vitro experiments have suggested that some fatty acids including lauric acid could be a useful component in a treatment for acne, but no clinical trials have yet been conducted to evaluate this potential benefit in humans. Lauric acid increases total serum cholesterol more than many other fatty acids. But most of the increase is attributable to an increase in high-density lipoprotein (HDL) (the "good" blood cholesterol). As a result, lauric acid has been characterized as having "a more favorable effect on total HDL cholesterol than any other fatty acid, either saturated or unsaturated.
Hodoodo Cat#: H328034
Name: Lauric acid
CAS#: 143-07-7
Chemical Formula: C12H24O2
Exact Mass: 200.18
Molecular Weight: 200.322
Elemental Analysis: C, 71.95; H, 12.08; O, 15.97
Synonym: Vulvic acid; Dodecanoic Acid; Lauric acid; GT-08; GT 08; GT08.
IUPAC/Chemical Name: Dodecanoic Acid
InChi Key: POULHZVOKOAJMA-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)
SMILES Code: CCCCCCCCCCCC(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 200.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Lekshmi Sheela D, Nazeem PA, Narayanankutty A, Manalil JJ, Raghavamenon AC. In Silico and Wet Lab Studies Reveal the Cholesterol Lowering Efficacy of Lauric Acid, a Medium Chain Fat of Coconut Oil. Plant Foods Hum Nutr. 2016 Sep 27. PubMed PMID: 27679437.
2: McCarty MF, DiNicolantonio JJ. Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity. Open Heart. 2016 Jul 27;3(2):e000467. doi: 10.1136/openhrt-2016-000467. Review. PubMed PMID: 27547436; PubMed Central PMCID: PMC4975867.
3: Uehara S, Uno Y, Ishii S, Inoue T, Sasaki E, Yamazaki H. Marmoset cytochrome P450 4A11, a novel arachidonic acid and lauric acid ω-hydroxylase expressed in liver and kidney tissues. Xenobiotica. 2016 Jul 20:1-9. PubMed PMID: 27435360.
4: Nonaka Y, Takagi T, Inai M, Nishimura S, Urashima S, Honda K, Aoyama T, Terada S. Lauric Acid Stimulates Ketone Body Production in the KT-5 Astrocyte Cell Line. J Oleo Sci. 2016 Aug 1;65(8):693-9. doi: 10.5650/jos.ess16069. PubMed PMID: 27430387.
5: Muniyan R, Gurunathan J. Lauric acid and myristic acid from Allium sativum inhibit the growth of Mycobacterium tuberculosis H37Ra: in silico analysis reveals possible binding to protein kinase B. Pharm Biol. 2016 Jun 16:1-8. PubMed PMID: 27307092.
6: Weng WH, Leung WH, Pang YJ, Hsu HH. Lauric acid can improve the sensitization of Cetuximab in KRAS/BRAF mutated colorectal cancer cells by retrievable microRNA-378 expression. Oncol Rep. 2016 Jan;35(1):107-16. doi: 10.3892/or.2015.4336. PubMed PMID: 26496897.
7: Silva EL, Carneiro G, De Araújo LA, Trindade Mde J, Yoshida MI, Oréfice RL, Farias Lde M, De Carvalho MA, Dos Santos SG, Goulart GA, Alves RJ, Ferreira LA. Solid Lipid Nanoparticles Loaded with Retinoic Acid and Lauric Acid as an Alternative for Topical Treatment of Acne Vulgaris. J Nanosci Nanotechnol. 2015 Jan;15(1):792-9. PubMed PMID: 26328443.
8: Zaloga J, Stapf M, Nowak J, Pöttler M, Friedrich RP, Tietze R, Lyer S, Lee G, Odenbach S, Hilger I, Alexiou C. Tangential Flow Ultrafiltration Allows Purification and Concentration of Lauric Acid-/Albumin-Coated Particles for Improved Magnetic Treatment. Int J Mol Sci. 2015 Aug 14;16(8):19291-307. doi: 10.3390/ijms160819291. PubMed PMID: 26287178; PubMed Central PMCID: PMC4581297.
9: Work VH, Melnicki MR, Hill EA, Davies FK, Kucek LA, Beliaev AS, Posewitz MC. Lauric Acid Production in a Glycogen-Less Strain of Synechococcus sp. PCC 7002. Front Bioeng Biotechnol. 2015 Apr 24;3:48. doi: 10.3389/fbioe.2015.00048. PubMed PMID: 25964950; PubMed Central PMCID: PMC4408914.
10: Yamashita S, Igarashi M, Hayashi C, Shitara T, Nomoto A, Mizote T, Shibasaki M. Identification of self-growth-inhibiting compounds lauric acid and 7-(Z)-tetradecenoic acid from Helicobacter pylori. Microbiology. 2015 Jun;161(6):1231-9. doi: 10.1099/mic.0.000077. PubMed PMID: 25767109.
11: Zaloga J, Janko C, Nowak J, Matuszak J, Knaup S, Eberbeck D, Tietze R, Unterweger H, Friedrich RP, Duerr S, Heimke-Brinck R, Baum E, Cicha I, Dörje F, Odenbach S, Lyer S, Lee G, Alexiou C. Development of a lauric acid/albumin hybrid iron oxide nanoparticle system with improved biocompatibility. Int J Nanomedicine. 2014 Oct 20;9:4847-66. doi: 10.2147/IJN.S68539. PubMed PMID: 25364244; PubMed Central PMCID: PMC4211907.
12: Rajesh PP, Noori MT, Ghangrekar MM. Controlling methanogenesis and improving power production of microbial fuel cell by lauric acid dosing. Water Sci Technol. 2014;70(8):1363-9. doi: 10.2166/wst.2014.386. PubMed PMID: 25353941.
13: Kim D, Cha GS, Nagy LD, Yun CH, Guengerich FP. Kinetic analysis of lauric acid hydroxylation by human cytochrome P450 4A11. Biochemistry. 2014 Oct 7;53(39):6161-72. doi: 10.1021/bi500710e. PubMed PMID: 25203493; PubMed Central PMCID: PMC4188250.
14: Jamuna-Thevi K, Saarani NN, Abdul Kadir MR, Hermawan H. Triple-layered PLGA/nanoapatite/lauric acid graded composite membrane for periodontal guided bone regeneration. Mater Sci Eng C Mater Biol Appl. 2014 Oct;43:253-63. doi: 10.1016/j.msec.2014.07.028. PubMed PMID: 25175212.
15: Chang F, He X, Fu X, Huang Q, Jane JL. Effects of heat treatment and moisture contents on interactions between lauric acid and starch granules. J Agric Food Chem. 2014 Aug 6;62(31):7862-8. doi: 10.1021/jf501606w. PubMed PMID: 25056554.
16: Faciola AP, Broderick GA. Effects of feeding lauric acid or coconut oil on ruminal protozoa numbers, fermentation pattern, digestion, omasal nutrient flow, and milk production in dairy cows. J Dairy Sci. 2014;97(8):5088-100. doi: 10.3168/jds.2013-7653. PubMed PMID: 24931520.
17: Zhao L, Hu Y, Xu D, Cai K. Surface functionalization of titanium substrates with chitosan-lauric acid conjugate to enhance osteoblasts functions and inhibit bacteria adhesion. Colloids Surf B Biointerfaces. 2014 Jul 1;119:115-25. doi: 10.1016/j.colsurfb.2014.05.002. PubMed PMID: 24880988.
18: Shankar S, Agarwal M, Chaurasia SP. Study of reaction parameters and kinetics of esterification of lauric acid with butanol by immobilized Candida antarctica lipase. Indian J Biochem Biophys. 2013 Dec;50(6):570-6. PubMed PMID: 24772983.
19: Pan H, Jiang B, Chen J, Jin Z. Blend-modification of soy protein/lauric acid edible films using polysaccharides. Food Chem. 2014 May 15;151:1-6. doi: 10.1016/j.foodchem.2013.11.075. PubMed PMID: 24423494.
20: Fauser JK, Matthews GM, Cummins AG, Howarth GS. Induction of apoptosis by the medium-chain length fatty acid lauric acid in colon cancer cells due to induction of oxidative stress. Chemotherapy. 2013;59(3):214-24. doi: 10.1159/000356067. PubMed PMID: 24356281.
