WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526156
CAS#: 111252-13-2
Description: Ro 16-3177 is a metabolite of moclobemide.
Hodoodo Cat#: H526156
Name: Ro 16-3177
CAS#: 111252-13-2
Chemical Formula: C11H15ClN2O2
Exact Mass: 242.08
Molecular Weight: 242.700
Elemental Analysis: C, 54.44; H, 6.23; Cl, 14.61; N, 11.54; O, 13.18
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Synonym: Ro 16-3177; Ro16-3177; Ro-16-3177.
IUPAC/Chemical Name: 4-Chloro-N-(2-((2-hydroxyethyl)amino)ethyl)benzamide
InChi Key: SPHJOGBBUGIRAM-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H15ClN2O2/c12-10-3-1-9(2-4-10)11(16)14-6-5-13-7-8-15/h1-4,13,15H,5-8H2,(H,14,16)
SMILES Code: O=C(NCCNCCO)C1=CC=C(Cl)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 242.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Skibiński R, Komsta Ł. Application of curve resolution algorithms in the study of drug photodegradation kinetics -- the example of moclobemide. J AOAC Int. 2012 May-Jun;95(3):708-12. PubMed PMID: 22816261.
2: Misztal G, Skibiński R, Olajossy M, Paw B. LC determination of moclobemide and three metabolites in plasma. J Pharm Biomed Anal. 2002 Nov 7;30(4):1277-85. PubMed PMID: 12408918.
3: Vallès B, Coassolo P, De Sousa G, Aubert C, Rahmani R. In vitro hepatic biotransformation of moclobemide (Ro 11-1163) in man and rat. Xenobiotica. 1993 Oct;23(10):1101-11. PubMed PMID: 8259692.
4: Schoerlin MP, Da Prada M. Species-specific biotransformation of moclobemide: a comparative study in rats and humans. Acta Psychiatr Scand Suppl. 1990;360:108-10. PubMed PMID: 2248061.