YM-430

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H526940

CAS#: 153192-22-4

Description: YM-430, also known as YM-15430; YM-154301; is a dual of β1 adrenergic receptor antagonist and calcium channel antagonist. YM430 could be both an antianginal and antihypertensive agent, because of its dual activities. YM430 (10(-8)-10(-6) M) inhibited 3,4-diaminopyridine-induced rhythmic contractions with an IC50 value of 59.2 nM. In anesthetized rats, YM430 (10-100 mg/kg PO) inhibited arginine vasopressin-induced ST-segment depression with an IC50 value of 36.6 mg/kg PO. YM430 may be of value in the treatment of various types of angina pectoris such as variant and stable angina.

Chemical Structure

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YM-430
CAS# 153192-22-4
Instruction

Theoretical Analysis

Hodoodo Cat#: H526940
Name: YM-430
CAS#: 153192-22-4
Chemical Formula: C29H35N3O8
Exact Mass: 553.24
Molecular Weight: 553.612
Elemental Analysis: C, 62.92; H, 6.37; N, 7.59; O, 23.12

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: YM-15430; YM-154301; YM-15430-1; YM-15430-2; YM-15430-3; YM430; YM-430; YM 430.

IUPAC/Chemical Name: 3-(4-(((S)-2-hydroxy-3-phenoxypropyl)amino)butyl) 5-methyl (S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

InChi Key: HBXMSJLNXYLVTA-HOFKKMOUSA-N

InChi Code: InChI=1S/C29H35N3O8/c1-19-25(28(34)38-3)27(21-10-9-11-22(16-21)32(36)37)26(20(2)31-19)29(35)39-15-8-7-14-30-17-23(33)18-40-24-12-5-4-6-13-24/h4-6,9-13,16,23,27,30-31,33H,7-8,14-15,17-18H2,1-3H3/t23-,27-/m0/s1

SMILES Code: O=C(C1=C(C)NC(C)=C(C(OCCCCNC[C@H](O)COC2=CC=CC=C2)=O)[C@H]1C3=CC=CC([N+]([O-])=O)=C3)OC

Appearance: White to off-white solid powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 553.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sasaki S, Nakagawa M. [Calcium channel blocker for therapy of patients with hypertension]. Nihon Rinsho. 1997 Aug;55(8):2061-6. Review. Japanese. PubMed PMID: 9284424.

2: Shibasaki K, Arai Y, Uchida W, Okazaki T, Asano M, Takenaka T. Antianginal effects of YM430, a novel calcium entry-blocking and beta-adrenoceptor-blocking agent in several experimental angina models. Gen Pharmacol. 1997 Oct;29(4):545-50. PubMed PMID: 9352300.

3: Shibasaki K, Uchida W, Takizawa K, Masuda N, Okazaki T, Inagaki O, Asano M, Takenaka T. Cardiovascular effects of YM430, a 1,4-dihydropyridine derivative with beta-adrenoceptor blocking activity, in dogs and rats. Biol Pharm Bull. 1997 Mar;20(3):230-6. PubMed PMID: 9084878.

4: Shibasaki K, Takizawa K, Uchida W, Takenaka T. Hypotensive effects of YM430, a 1,4-dihydropyridine derivative, in spontaneously hypertensive rats and renal hypertensive dogs. Jpn J Pharmacol. 1997 Feb;73(2):113-24. PubMed PMID: 9074945.