ND-336 hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H526968

CAS#: 1807453-83-3 (HCl)

Description: ND-336 is a novel highly selective inhibitor of gelatinases (MMP-2 and MMP-9) and MMP-14. ND-336 accelerates diabetic wound healing by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound, thereby reversing the pathological condition. ND-336 holds considerable promise in healing of diabetic wounds.

Chemical Structure

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ND-336 hydrochloride
CAS# 1807453-83-3 (HCl)
Instruction

Theoretical Analysis

Hodoodo Cat#: H526968
Name: ND-336 hydrochloride
CAS#: 1807453-83-3 (HCl)
Chemical Formula: C16H18ClNO3S2
Exact Mass: 0.00
Molecular Weight: 371.894
Elemental Analysis: C, 51.67; H, 4.88; Cl, 9.53; N, 3.77; O, 12.91; S, 17.24

Price and Availability

Size Price Availability Quantity
5mg USD -1 2 Weeks
10mg USD -1 2 Weeks
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Related CAS #: 1807453-71-9 (free base)   1807453-83-3 (HCl)    

Synonym: ND-336; ND 336; ND336; ND-336 hydrochloride; ND-336 HCl,

IUPAC/Chemical Name: (4-(4-((thiiran-2-ylmethyl)sulfonyl)phenoxy)phenyl)methanamine hydrochloride

InChi Key: DRGIZFGSEKSFIC-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H17NO3S2.ClH/c17-9-12-1-3-13(4-2-12)20-14-5-7-16(8-6-14)22(18,19)11-15-10-21-15;/h1-8,15H,9-11,17H2;1H

SMILES Code: NCC(C=C1)=CC=C1OC2=CC=C(S(CC3SC3)(=O)=O)C=C2.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 371.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chang M. Restructuring of the extracellular matrix in diabetic wounds and
healing: A perspective. Pharmacol Res. 2016 May;107:243-8. doi:
10.1016/j.phrs.2016.03.008. PubMed PMID: 27033051.


2: Jiang ZL, Sun YC, Wang ZB, Liang ZB, Ren K, Xie ZL, Zhang M, Liao Y.
[Variation Characteristics and Sources of Polycyclic Aromatic Hydrocarbons in
Karst Subterranean River During Rainfall Events]. Huan Jing Ke Xue. 2015
Nov;36(11):4088-94. Chinese. PubMed PMID: 26910994.


3: Gao M, Nguyen TT, Suckow MA, Wolter WR, Gooyit M, Mobashery S, Chang M.
Acceleration of diabetic wound healing using a novel protease-anti-protease
combination therapy. Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15226-31. doi:
10.1073/pnas.1517847112. PubMed PMID: 26598687; PubMed Central PMCID: PMC4679041.