WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H530304
CAS#: 1817626-54-2
Description: PF-06650833, also known as Zimlovisertib, is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4). RAK4 is located proximal to TLR/IL-1 receptors, and in preclinical studies, inhibits downstream signaling from these receptors. The development of novel small molecule inhibitors of this kinase has the potential to lead to new therapeutics to treat diseases such as rheumatoid arthritis, lupus, and lymphomas.
Hodoodo Cat#: H530304
Name: PF-06650833
CAS#: 1817626-54-2
Chemical Formula: C18H20FN3O4
Exact Mass: 361.14
Molecular Weight: 361.373
Elemental Analysis: C, 59.83; H, 5.58; F, 5.26; N, 11.63; O, 17.71
Synonym: PF-06650833; PF 06650833; PF06650833; PF-6650833; PF 6650833; PF6650833, Zimlovisertib
IUPAC/Chemical Name: 1-[[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy-6-isoquinolinecarboxamide
InChi Key: JKDGKIBAOAFRPJ-ZBINZKHDSA-N
InChi Code: InChI=1S/C18H20FN3O4/c1-3-10-13(22-17(24)15(10)19)8-26-18-11-7-14(25-2)12(16(20)23)6-9(11)4-5-21-18/h4-7,10,13,15H,3,8H2,1-2H3,(H2,20,23)(H,22,24)/t10-,13+,15-/m0/s1
SMILES Code: O=C(C1=CC2=C(C(OC[C@H]([C@H](CC)[C@@H]3F)NC3=O)=NC=C2)C=C1OC)N
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 361.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Seganish WM. Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4):
a patent review (2012-2015). Expert Opin Ther Pat. 2016 Aug;26(8):917-32. doi:
10.1080/13543776.2016.1202926. PubMed PMID: 27310003.