PF-06281355
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Hodoodo CAT#: H531253

CAS#: 1435467-38-1

Description: PF-06281355, also known as PF-1355, is an orally available, selective and potent mechanism based inhibitor of the myeloperoxidase (MPO) that reduces plasma MPO activity, vascular edema, neutrophil recruitment, and elevated circulating cytokines. PF-06281355 suppresses albuminuria and chronic renal dysfunction in model of anti-Glomerular Basement Membrane (GBM) disease. PF-1355 prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis.

Chemical Structure

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PF-06281355
CAS# 1435467-38-1
Instruction

Theoretical Analysis

Hodoodo Cat#: H531253
Name: PF-06281355
CAS#: 1435467-38-1
Chemical Formula: C14H15N3O4S
Exact Mass: 321.08
Molecular Weight: 321.351
Elemental Analysis: C, 52.33; H, 4.71; N, 13.08; O, 19.91; S, 9.98

Price and Availability

Size Price Availability Quantity
100mg USD 650 2 Weeks
200mg USD 950 2 Weeks
500mg USD 1650 2 Weeks
1g USD 2650 2 Weeks
2g USD 3950 2 Weeks
5g USD 5850 2 Weeks
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Synonym: PF-06281355; PF 06281355; PF06281355; PF-1355; PF 1355; PF1355.

IUPAC/Chemical Name: 2-(6-(2,5-Dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide

InChi Key: LJBUZOGABRDGBR-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H15N3O4S/c1-20-8-3-4-11(21-2)9(5-8)10-6-13(19)16-14(22)17(10)7-12(15)18/h3-6H,7H2,1-2H3,(H2,15,18)(H,16,19,22)

SMILES Code: O=C(N)CN(C(N1)=S)C(C2=CC(OC)=CC=C2OC)=CC1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 321.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zheng W, Warner R, Ruggeri R, Su C, Cortes C, Skoura A, Ward J, Ahn K,
Kalgutkar A, Sun D, Maurer TS, Bonin PD, Okerberg C, Bobrowski W, Kawabe T, Zhang
Y, Coskran T, Bell S, Kapoor B, Johnson K, Buckbinder L. PF-1355, a
mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and
anti-glomerular basement membrane glomerulonephritis. J Pharmacol Exp Ther. 2015
May;353(2):288-98. doi: 10.1124/jpet.114.221788. PubMed PMID: 25698787.