WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H530103
CAS#: 651331-92-9
Description: UR-1505 is a nuclear factor of activated T cells (NF-AT) inhibitor potentially for the treatment of atopic dermatitis. UR-1505 acts by means of a specific mechanism inhibiting T cell activation depending on T cell receptor signaling pathway. Furthermore, the antiproliferative effects of UR-1505 are not a consequence of decreased cell viability.
Hodoodo Cat#: H530103
Name: UR-1505
CAS#: 651331-92-9
Chemical Formula: C10H7F5O4
Exact Mass: 286.03
Molecular Weight: 286.154
Elemental Analysis: C, 41.97; H, 2.47; F, 33.20; O, 22.36
This product is not in stock, which may be available by custom synthesis.
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Synonym: UR-1505, UR1505, UR 1505
IUPAC/Chemical Name: 2-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoic Acid
InChi Key: BLEWPNAUDGZWPU-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H7F5O4/c11-9(12,10(13,14)15)4-19-5-1-2-6(8(17)18)7(16)3-5/h1-3,16H,4H2,(H,17,18)
SMILES Code: O=C(O)C1=CC=C(OCC(F)(F)C(F)(F)F)C=C1O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 286.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Vives R, Pontes C, Sarasa M, Millier A. Safety and Activity of UR-1505 in Atopic Dermatitis: A Randomized, Double-blind Phase II Exploratory Trial. Clin Ther. 2015 Sep 1;37(9):1955-65. doi: 10.1016/j.clinthera.2015.06.005. PubMed PMID: 26163200.
2: Román J, de Arriba AF, Barrón S, Michelena P, Giral M, Merlos M, Bailón E, Comalada M, Gálvez J, Zarzuelo A, Ramis I. UR-1505, a new salicylate, blocks T cell activation through nuclear factor of activated T cells. Mol Pharmacol. 2007 Aug;72(2):269-79. PubMed PMID: 17475810.
3: Bailón E, Román J, Ramis I, Michelena P, Balsa D, Merlos M, Zarzuelo A, Gálvez J, Comalada M. The new salicylate derivative UR-1505 modulates the Th2/humoral response in a dextran sodium sulphate model of colitis that resembles ulcerative colitis. J Pharmacol Sci. 2009 Feb;109(2):315-8. PubMed PMID: 19234369.
4: Bailón E, Comalada M, Román J, Michelena P, Ramis I, Merlos M, Nieto A, Concha A, Zarzuelo A, Gálvez J. UR-1505, a salicylate able to selectively block T-cell activation, shows intestinal anti-inflammatory activity in the chronic phase of the DSS model of rat colitis. Inflamm Bowel Dis. 2008 Jul;14(7):888-97. doi: 10.1002/ibd.20381. PubMed PMID: 18253952.
5: Bailón E, Camuesco D, Nieto A, Concha A, Fernández de Arriba A, Román J, Ramis I, Merlos M, Zarzuelo A, Gálvez J, Comalada M. The intestinal anti-inflammatory effects of the novel agent UR-1505 in the TNBS model of rat colitis are mediated by T-lymphocyte inhibition. Biochem Pharmacol. 2007 Nov 15;74(10):1496-506. PubMed PMID: 17720145.
