WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526443
CAS#: 21925-88-2
Description: Tesicam is a bioactive chemical.
Hodoodo Cat#: H526443
Name: Tesicam
CAS#: 21925-88-2
Chemical Formula: C16H11ClN2O3
Exact Mass: 314.05
Molecular Weight: 314.725
Elemental Analysis: C, 61.06; H, 3.52; Cl, 11.26; N, 8.90; O, 15.25
This product is not in stock, which may be available by custom synthesis.
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Synonym: Tesicam
IUPAC/Chemical Name: 4-Isoquinolinecarboxamide, N-(4-chlorophenyl)-1,2,3,4-tetrahydro-1,3-dioxo-
InChi Key: HWCORKBTTGTRDY-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H11ClN2O3/c17-9-5-7-10(8-6-9)18-15(21)13-11-3-1-2-4-12(11)14(20)19-16(13)22/h1-8,13H,(H,18,21)(H,19,20,22)
SMILES Code: O=C(C(C1=C2C=CC=C1)C(NC2=O)=O)NC3=CC=C(Cl)C=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 314.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: User, Ostojic M, Beleslin B, Stojkovic S, Nedeljkovic M, Tesic M, Kondru PR, Zhang Y, Asanin M. TCT-179 Are there STEMI patients in whom manual thrombus aspiration is superior compared to standard primary PCI? Subanalysis of PATA STEMI trial. J Am Coll Cardiol. 2016 Nov 1;68(18S):B73-B74. doi: 10.1016/j.jacc.2016.09.321. PubMed PMID: 27970348.
2: Ciampi Q, Olivotto I, Gardini C, Mori F, Peteiro J, Monserrat L, Fernandez X, Cortigiani L, Rigo F, Lopes LR, Cruz I, Cotrim C, Losi M, Betocchi S, Beleslin B, Tesic M, Dikic AD, Lazzeroni E, Lazzeroni D, Sicari R, Picano E. Prognostic role of stress echocardiography in hypertrophic cardiomyopathy: The International Stress Echo Registry. Int J Cardiol. 2016 Sep 15;219:331-8. doi: 10.1016/j.ijcard.2016.06.044. PubMed PMID: 27348413.
3: Nedeljković MA, Beleslin B, Tesić M, Vukcević V, Stanković G, Stojković S, Orlić D, Bilbija I, Matković M, Simić T, Menković N, Mrdović I, Ussia GP, Perisić Z, Babić M. Percutaneous implantation of self-expandable aortic valve in high risk patients with severe aortic stenosis: The first experiences in Serbia. Vojnosanit Pregl. 2016 Feb;73(2):192-7. PubMed PMID: 27071288.
4: Dikic M, Tesic M, Markovic Z, Giga V, Djordjevic-Dikic A, Stepanovic J, Beleslin B, Jovanovic I, Mladenovic A, Seferovic J, Ostojic M, Arandjelovic A. Prognostic value of calcium score and coronary flow velocity reserve in asymptomatic diabetic patients. Cardiovasc Ultrasound. 2015 Sep 4;13:41. doi: 10.1186/s12947-015-0035-2. PubMed PMID: 26340922; PubMed Central PMCID: PMC4560883.
5: Lipovac K, Tešić M, Marić B, Đerić M. Self-reported and observed seat belt use--A case study: Bosnia and Herzegovina. Accid Anal Prev. 2015 Nov;84:74-82. doi: 10.1016/j.aap.2015.08.010. PubMed PMID: 26320737.
6: Kostic J, Djordjevic-Dikic A, Dobric M, Milasinovic D, Nedeljkovic M, Stojkovic S, Stepanovic J, Tesic M, Trifunovic Z, Zamaklar-Tifunovic D, Radosavljevic-Radovanovic M, Ostojic M, Beleslin B. The effects of nicorandil on microvascular function in patients with ST segment elevation myocardial infarction undergoing primary PCI. Cardiovasc Ultrasound. 2015 May 27;13:26. doi: 10.1186/s12947-015-0020-9. PubMed PMID: 26012474; PubMed Central PMCID: PMC4446834.
7: Ljubic A, Trajkovski V, Tesic M, Tojtovska B, Stankovic B. Ophthalmic manifestations in children and young adults with Down syndrome and congenital heart defects. Ophthalmic Epidemiol. 2015 Apr;22(2):123-9. doi: 10.3109/09286586.2015.1017652. PubMed PMID: 25777312.
8: Tesić M, Stanković G. Is there enough evidence for routine use of drug-eluting stents in acute myocardial infarction with ST segment elevation? Vojnosanit Pregl. 2014 Sep;71(9):870-4. Review. PubMed PMID: 25282786.
9: Kostić J, Orlić D, Borović ML, Beleslin B, Milašinović D, Dobrić M, Tešić M, Ostojić M. Coronary thrombi neovascularization in patients with ST-elevation myocardial infarction - clinical and angiographic implications. Thromb Res. 2014 Nov;134(5):1038-45. doi: 10.1016/j.thromres.2014.09.012. PubMed PMID: 25262107.
10: Trifunovic D, Sobic-Saranovic D, Beleslin B, Stankovic S, Marinkovic J, Orlic D, Vujisic-Tesic B, Petrovic M, Nedeljkovic I, Banovic M, Djukanovic N, Petrovic O, Petrovic M, Stepanovic J, Djordjevic-Dikic A, Tesic M, Ostojic M. Coronary flow of the infarct artery assessed by transthoracic Doppler after primary percutaneous coronary intervention predicts final infarct size. Int J Cardiovasc Imaging. 2014 Dec;30(8):1509-18. doi: 10.1007/s10554-014-0497-6. PubMed PMID: 25108390.
11: Djordjevic Dikic A, Nikcevic G, Raspopovic S, Jovanovic V, Tesic M, Beleslin B, Stepanovic J, Giga V, Milasinovic G. Prognostic role of coronary flow reserve for left ventricular functional improvement after cardiac resynchronization therapy in patients with dilated cardiomyopathy. Eur Heart J Cardiovasc Imaging. 2014 Dec;15(12):1344-9. doi: 10.1093/ehjci/jeu136. PubMed PMID: 25053732.
12: Trifunovic D, Stankovic S, Marinkovic J, Beleslin B, Banovic M, Djukanovic N, Orlic D, Tesic M, Vujisic-Tesic B, Petrovic M, Nedeljkovic I, Stepanovic J, Djordjevic-Dikic A, Giga V, Ostojic M. Time-dependent changes of plasma adiponectin concentration in relation to coronary microcirculatory function in patients with acute myocardial infarction treated by primary percutaneous coronary intervention. J Cardiol. 2015 Mar;65(3):208-15. doi: 10.1016/j.jjcc.2014.05.011. PubMed PMID: 25012060.
13: Seferović JP, Milinković I, Tešić M, Ristić A, Lalić N, Simeunović D, Zivković I, Di Somma S, Seferovic PM. The role of glycemia in acute heart failure patients. Clin Chem Lab Med. 2014 Oct;52(10):1437-46. doi: 10.1515/cclm-2014-0239. Review. PubMed PMID: 24988247.
14: Seferovic JP, Lalic NM, Floridi F, Tesic M, Seferovic PM, Giga V, Lalic K, Jotic A, Jovicic S, Colak E, Salerno G, Cardelli P, Di Somma S. Structural myocardial alterations in diabetes and hypertension: the role of galectin-3. Clin Chem Lab Med. 2014 Oct;52(10):1499-505. doi: 10.1515/cclm-2014-0265. PubMed PMID: 24887961.
15: Trifunovic D, Stankovic S, Sobic-Saranovic D, Marinkovic J, Petrovic M, Orlic D, Beleslin B, Banovic M, Vujisic-Tesic B, Petrovic M, Nedeljkovic I, Stepanovic J, Djordjevic-Dikic A, Tesic M, Djukanovic N, Petrovic O, Vasovic O, Nestorovic E, Kostic J, Ristic A, Ostojic M. Acute insulin resistance in ST-segment elevation myocardial infarction in non-diabetic patients is associated with incomplete myocardial reperfusion and impaired coronary microcirculatory function. Cardiovasc Diabetol. 2014 Apr 5;13:73. doi: 10.1186/1475-2840-13-73. PubMed PMID: 24708817; PubMed Central PMCID: PMC4234386.
16: Orlic D, Ostojic M, Beleslin B, Milasinovic D, Tesic M, Borovic M, Vukcevic V, Stojkovic S, Nedeljkovic M, Stankovic G. The randomized physiologic assessment of thrombus aspiration in patients with acute ST-segment elevation myocardial infarction trial (PATA STEMI): study rationale and design. J Interv Cardiol. 2014 Aug;27(4):341-7. doi: 10.1111/joic.12105. PubMed PMID: 24571619.
17: Giugliano RP, Ruff CT, Braunwald E, Murphy SA, Wiviott SD, Halperin JL, Waldo AL, Ezekowitz MD, Weitz JI, Špinar J, Ruzyllo W, Ruda M, Koretsune Y, Betcher J, Shi M, Grip LT, Patel SP, Patel I, Hanyok JJ, Mercuri M, Antman EM; ENGAGE AF-TIMI 48 Investigators.. Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2013 Nov 28;369(22):2093-104. doi: 10.1056/NEJMoa1310907. PubMed PMID: 24251359.
18: Andjelkovic K, Kalimanovska-Ostric D, Djukic M, Vukcevic V, Menkovic N, Mehmedbegovic Z, Topalovic M, Tesic M. Two rare conditions in an Eisenmenger patient: left main coronary artery compression and Ortner's syndrome due to pulmonary artery dilatation. Heart Lung. 2013 Sep-Oct;42(5):382-6. doi: 10.1016/j.hrtlng.2013.06.001. PubMed PMID: 23831302.
19: Dobric M, Giga V, Beleslin B, Ignjatovic S, Paunovic I, Stepanovic J, Djordjevic-Dikic A, Kostic J, Nedeljkovic I, Nedeljkovic M, Tesic M, Dajak M, Ostojic M. Glycogen phosphorylase isoenzyme BB plasma kinetics is not related to myocardial ischemia induced by exercise stress echo test. Clin Chem Lab Med. 2013 Oct;51(10):2029-35. doi: 10.1515/cclm-2013-0109. PubMed PMID: 23729628.
20: Tesic M, Djordjevic-Dikic A, Beleslin B, Trifunovic D, Giga V, Marinkovic J, Petrovic O, Petrovic M, Stepanovic J, Dobric M, Vukcevic V, Stankovic G, Seferovic P, Ostojic M, Vujisic-Tesic B. Regional difference of microcirculation in patients with asymmetric hypertrophic cardiomyopathy: transthoracic Doppler coronary flow velocity reserve analysis. J Am Soc Echocardiogr. 2013 Jul;26(7):775-82. doi: 10.1016/j.echo.2013.03.023. PubMed PMID: 23643850.
