WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H530465
CAS#: 1093757-42-6
Description: UV0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively).
Hodoodo Cat#: H530465
Name: UV-0155041
CAS#: 1093757-42-6
Chemical Formula: C14H15Cl2NO3
Exact Mass: 315.04
Molecular Weight: 316.178
Elemental Analysis: C, 53.18; H, 4.78; Cl, 22.42; N, 4.43; O, 15.18
Synonym: UV0155041; UV-0155041; UV 0155041.
IUPAC/Chemical Name: cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylic acid
InChi Key: VSMUYYFJVFSVCA-NWDGAFQWSA-N
InChi Code: InChI=1S/C14H15Cl2NO3/c15-8-5-9(16)7-10(6-8)17-13(18)11-3-1-2-4-12(11)14(19)20/h5-7,11-12H,1-4H2,(H,17,18)(H,19,20)/t11-,12+/m0/s1
SMILES Code: O=C([C@H]1[C@@H](C(NC2=CC(Cl)=CC(Cl)=C2)=O)CCCC1)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Related CAS# 1259372-69-4 (sodium salt) 1093757-42-6 (free acid)
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 316.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Niswender CM, Johnson KA, Weaver CD, Jones CK, Xiang Z, Luo Q, Rodriguez AL,
Marlo JE, de Paulis T, Thompson AD, Days EL, Nalywajko T, Austin CA, Williams MB,
Ayala JE, Williams R, Lindsley CW, Conn PJ. Discovery, characterization, and
antiparkinsonian effect of novel positive allosteric modulators of metabotropic
glutamate receptor 4. Mol Pharmacol. 2008 Nov;74(5):1345-58. doi:
10.1124/mol.108.049551. PubMed PMID: 18664603; PubMed Central PMCID: PMC2574552.
