WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526527
CAS#: 101621-29-8
Description: UK 58852 is a polyether ionophore.
Hodoodo Cat#: H526527
Name: UK 58852
CAS#: 101621-29-8
Chemical Formula: C52H88O18
Exact Mass: 1,000.60
Molecular Weight: 1,001.258
Elemental Analysis: C, 62.38; H, 8.86; O, 28.76
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Synonym: UK 58852, UK58852, UK58852
IUPAC/Chemical Name: 2H-Pyran-2-acetic acid, tetrahydro-2-hydroxy-6-(1-(9-hydroxy-2,8-dimethyl-2-(octahydro-2-methyl-5'-(tetrahydro-6-hydroxy-3,5,6-trimethyl-2H-pyran-2-yl)-3'-((tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl)oxy)(2,2'-bifuran)-5-yl)-1,6-dioxaspiro(4,5)dec-7-yl)ethyl)-5-methoxy-3-methyl-4-((tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl)oxy)-, (2R-(2alpha,3alpha,4beta(2S*,5S*,6R*),5alpha,6beta(R*(2S*(2S*,2'R*,3'S*(2S*,5S*,6R*),5R*,5'R*(2S*,3S*,5R*,6S*)),5R*,7S*,8R*,9S*))))-
InChi Key: FERWJHOISPGQCT-NCWSHVJWSA-N
InChi Code: InChI=1S/C52H88O18/c1-26-22-27(2)50(10,56)67-42(26)36-23-37(63-40-16-14-34(58-11)31(6)61-40)47(64-36)49(9)19-18-38(66-49)48(8)20-21-51(70-48)24-33(53)28(3)43(68-51)29(4)44-46(60-13)45(30(5)52(57,69-44)25-39(54)55)65-41-17-15-35(59-12)32(7)62-41/h26-38,40-47,53,56-57H,14-25H2,1-13H3,(H,54,55)/t26?,27?,28-,29+,30-,31?,32?,33+,34?,35-,36?,37+,38?,40?,41-,42?,43+,44-,45-,46-,47?,48?,49?,50?,51?,52+/m1/s1
SMILES Code: O=C(O)C[C@@]1(O)[C@H](C)[C@@H](O[C@@H]2CC[C@@H](OC)C(C)O2)[C@H](OC)[C@@H]([C@H]([C@H]([C@H](C)[C@@H](O)C3)OC43CCC(C5CCC(C6OC(C7C(C)CC(C)C(C)(O)O7)C[C@@H]6OC8CCC(OC)C(C)O8)(C)O5)(C)O4)C)O1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 1,001.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Ricketts AP, Chappel LR, Frame GM, Glazer EA, Migaki TT, Olson JA. CP-72,588, a semisynthetic analog of the polyether ionophore UK-58,582 with increased anticoccidial potency. Antimicrob Agents Chemother. 1992 Oct;36(10):2080-4. PubMed PMID: 1444288; PubMed Central PMCID: PMC245459.
2: Dirlam JP, Cullen WP, Huang LH, Nelson TH, Oscarson JR, Presseau-Linabury L, Tynan EJ, Whipple EB. CP-91,243 and CP-91,244, novel diglycoside polyether antibiotics related to UK-58,852 and produced by mutants of Actinomadura roseorufa. J Antibiot (Tokyo). 1991 Nov;44(11):1262-6. PubMed PMID: 1842675.