WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H529702
CAS#: 617720-02-2
Description: HT-0712 is phosphodiesterase (PDE4) inhibitor potentially for the treatment of age-associated memory impairment.
Hodoodo Cat#: H529702
Name: HT-0712
CAS#: 617720-02-2
Chemical Formula: C25H31NO3
Exact Mass: 393.23
Molecular Weight: 393.520
Elemental Analysis: C, 76.30; H, 7.94; N, 3.56; O, 12.20
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Synonym: HT-0712; IPL-455903; HT0712; IPL455903; HT 0712; IPL 455903
IUPAC/Chemical Name: (3S,5S)-5-(3-(cyclopentyloxy)-4-methoxyphenyl)-3-(3-methylbenzyl)piperidin-2-one
InChi Key: ABEJDMOBAFLQNJ-NHCUHLMSSA-N
InChi Code: InChI=1S/C25H31NO3/c1-17-6-5-7-18(12-17)13-20-14-21(16-26-25(20)27)19-10-11-23(28-2)24(15-19)29-22-8-3-4-9-22/h5-7,10-12,15,20-22H,3-4,8-9,13-14,16H2,1-2H3,(H,26,27)/t20-,21-/m1/s1
SMILES Code: O=C1NC[C@H](C2=CC=C(OC)C(OC3CCCC3)=C2)C[C@H]1CC4=CC=CC(C)=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 393.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Peters M, Bletsch M, Stanley J, Wheeler D, Scott R, Tully T. The PDE4 inhibitor HT-0712 improves hippocampus-dependent memory in aged mice. Neuropsychopharmacology. 2014 Dec;39(13):2938-48. doi: 10.1038/npp.2014.154. PubMed PMID: 24964813; PubMed Central PMCID: PMC4229572.
2: MacDonald E, Van der Lee H, Pocock D, Cole C, Thomas N, VandenBerg PM, Bourtchouladze R, Kleim JA. A novel phosphodiesterase type 4 inhibitor, HT-0712, enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemia. Neurorehabil Neural Repair. 2007 Nov-Dec;21(6):486-96. PubMed PMID: 17823313.
3: Giembycz MA. Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking? Br J Pharmacol. 2008 Oct;155(3):288-90. doi: 10.1038/bjp.2008.297. PubMed PMID: 18660832; PubMed Central PMCID: PMC2567889.
