WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H407379
CAS#: 729-46-4
Description: JX-06 is a potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor (IC50 values are 28, 49 and 313 nM for PDK2, PDK1 and PDK3, respectively). JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification. JX06, as a selective covalent inhibitor of PDK1 in cells, forms a disulfide bond with the thiol group of a conserved cysteine residue (C240) based on recognition of a hydrophobic pocket adjacent to the ATP pocket of the PDK1 enzyme.
Hodoodo Cat#: H407379
Name: JX-06
CAS#: 729-46-4
Chemical Formula: C10H16N2O2S4
Exact Mass: 324.01
Molecular Weight: 324.490
Elemental Analysis: C, 37.02; H, 4.97; N, 8.63; O, 9.86; S, 39.52
Synonym: JX-06; JX 06; JX06.
IUPAC/Chemical Name: Bis(morpholinothiocarbonyl) disulfide
InChi Key: KKVYOWPPMNSLCP-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H16N2O2S4/c15-9(11-1-5-13-6-2-11)17-18-10(16)12-3-7-14-8-4-12/h1-8H2
SMILES Code: S=C(SSC(N1CCOCC1)=S)N2CCOCC2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 324.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Sun W, Xie Z, Liu Y, Zhao D, Wu Z, Zhang D, Lv H, Tang S, Jin N, Jiang H, Tan
M, Ding J, Luo C, Li J, Huang M, Geng M. JX06 Selectively Inhibits Pyruvate
Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification. Cancer Res. 2015
Nov 15;75(22):4923-36. doi: 10.1158/0008-5472.CAN-15-1023. PubMed PMID: 26483203.
