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CYM-5541
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H530505

CAS#: 945128-26-7

Description: CYM-5541 is a selective, allosteric agonist of S1P3 (EC50 = 72-132 nM). Sphingosine 1-phosphate (S1P) is a lysophospholipid signaling molecule that regulates important biological functions, including lymphocyte trafficking and vascular development, by activating G protein-coupled receptors for S1P, namely, S1P(1) through S1P(5)

Chemical Structure

CYM-5541

CAS# 945128-26-7

Instruction

Theoretical Analysis

Hodoodo Cat#: H530505
Name: CYM-5541
CAS#: 945128-26-7
Chemical Formula: C19H28N2O2
Exact Mass: 316.22
Molecular Weight: 316.445
Elemental Analysis: C, 72.12; H, 8.92; N, 8.85; O, 10.11

Price and Availability

Size	Price	Availability
100mg	USD 450	2 Weeks
200mg	USD 750	2 Weeks
500mg	USD 1550	2 Weeks
1g	USD 2850	2 Weeks
2g	USD 5150	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: CYM-5541; CYM 5541; CYM5541.

IUPAC/Chemical Name: N,N-dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide

InChi Key: NDKGACIWVAOUQH-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H28N2O2/c22-19(17-13-18(23-20-17)14-11-12-14)21(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h13-16H,1-12H2

SMILES Code: O=C(C1=NOC(C2CC2)=C1)N(C3CCCCC3)C4CCCCC4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 316.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Crowley E, Leung E, Reynisson J, Richardson A. Rapid changes in the ATG5-ATG16L1 complex following nutrient deprivation measured using NanoLuc Binary Technology (NanoBIT). FEBS J. 2020 Mar 4. doi: 10.1111/febs.15275. Epub ahead of print. PMID: 32129924.

2: Wang H, Huang H, Ding SF. Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of Endothelial progenitor cells via S1PR1/S1PR3/PI3K/Akt pathway. Cell Biol Int. 2018 Nov;42(11):1492-1502. doi: 10.1002/cbin.10991. Epub 2018 Jul 8. PMID: 29790626.

3: St-Cyr Giguère F, Attiori Essis S, Chagniel L, Germain M, Cyr M, Massicotte G. The sphingosine-1-phosphate receptor 1 agonist SEW2871 reduces Tau-Ser262 phosphorylation in rat hippocampal slices. Brain Res. 2017 Mar 1;1658:51-59. doi: 10.1016/j.brainres.2017.01.014. Epub 2017 Jan 16. PMID: 28104351.

4: Jo E, Bhhatarai B, Repetto E, Guerrero M, Riley S, Brown SJ, Kohno Y, Roberts E, Schürer SC, Rosen H. Novel selective allosteric and bitopic ligands for the S1P(3) receptor. ACS Chem Biol. 2012 Dec 21;7(12):1975-83. doi: 10.1021/cb300392z. Epub 2012 Sep 14. PMID: 22971058; PMCID: PMC3528827.

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CYM-5541 featured