KH-CB19
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H532002

CAS#: 1354037-26-5

Description: KH-CB19 is a potent and selective inhibitor of CDC2-like kinase (CLK) 1 and 4. KH-CB19 suppresses serine/arginine-rich protein phosphorylation by CLKs under proinflammatory conditions.

Chemical Structure

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KH-CB19
CAS# 1354037-26-5
Instruction

Theoretical Analysis

Hodoodo Cat#: H532002
Name: KH-CB19
CAS#: 1354037-26-5
Chemical Formula: C15H13Cl2N3O2
Exact Mass: 337.04
Molecular Weight: 338.190
Elemental Analysis: C, 53.27; H, 3.87; Cl, 20.96; N, 12.43; O, 9.46

Price and Availability

Size Price Availability Quantity
5mg USD 450 2 Weeks
10mg USD 850 2 Weeks
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Synonym: KH-CB19; KH CB19; KHCB19.

IUPAC/Chemical Name: ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methylindole-2-carboxylate

InChi Key: CXJCGSPAPOTTSF-VURMDHGXSA-N

InChi Code: InChI=1S/C15H13Cl2N3O2/c1-3-22-15(21)14-11(8(6-18)7-19)9-4-5-10(16)12(17)13(9)20(14)2/h4-6H,3,18H2,1-2H3/b8-6-

SMILES Code: O=C(C(N1C)=C(/C(C#N)=C\N)C2=C1C(Cl)=C(Cl)C=C2)OCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 338.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jain P, Karthikeyan C, Moorthy NS, Waiker DK, Jain AK, Trivedi P. Human CDC2-like kinase 1 (CLK1): a novel target for Alzheimer's disease. Curr Drug Targets. 2014 May;15(5):539-50. Review. PubMed PMID: 24568585.

2: Fedorov O, Huber K, Eisenreich A, Filippakopoulos P, King O, Bullock AN, Szklarczyk D, Jensen LJ, Fabbro D, Trappe J, Rauch U, Bracher F, Knapp S. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011 Jan 28;18(1):67-76. doi: 10.1016/j.chembiol.2010.11.009. PubMed PMID: 21276940; PubMed Central PMCID: PMC3145970.

3: Grant SK, Lunney EA. Kinase inhibition that hinges on halogen bonds. Chem Biol. 2011 Jan 28;18(1):3-4. doi: 10.1016/j.chembiol.2011.01.003. PubMed PMID: 21276931.