KT 5720
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H532045

CAS#: 108068-98-0

Description: KT 5720 is a potent, selective inhibitor of protein kinase A (Ki = 60 nM). KT 5720 reversibly arrests human skin fibroblasts in the G1 phase.

Chemical Structure

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KT 5720
CAS# 108068-98-0
Instruction

Theoretical Analysis

Hodoodo Cat#: H532045
Name: KT 5720
CAS#: 108068-98-0
Chemical Formula: C32H31N3O5
Exact Mass: 537.23
Molecular Weight: 537.616
Elemental Analysis: C, 71.49; H, 5.81; N, 7.82; O, 14.88

Price and Availability

Size Price Availability Quantity
100µg USD 350 2 Weeks
250µg USD 650 2 Weeks
500µg USD 950 2 Weeks
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Synonym: KT 5720; KT5720; KT-5720.

IUPAC/Chemical Name: hexyl (15R,16R,18S)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8,10,12,20,22,24-nonaene-16-carboxylate

InChi Key: ZHEHVZXPFVXKEY-IKZDWWSZSA-N

InChi Code: InChI=1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32-/m0/s1

SMILES Code: O=C([C@](C[C@@](O1)([H])N2C3=CC=CC=C43)(O)[C@]1(C)N5C6=CC=CC=C6C7=C5C2=C4C8=C7CNC8=O)OCCCCCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 537.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Galski H, Sivan H, Lazarovici P, Nagler A. In vitro and in vivo reversal of MDR1-mediated multidrug resistance by KT-5720: implications on hematological malignancies. Leuk Res. 2006 Sep;30(9):1151-8. PubMed PMID: 16542724.

2: Galski H, Lazarovici P, Gottesman MM, Murakata C, Matsuda Y, Hochman J. KT-5720 reverses multidrug resistance in variant S49 mouse lymphoma cells transduced with the human MDR1 cDNA and in human multidrug-resistant carcinoma cells. Eur J Cancer. 1995;31A(3):380-8. PubMed PMID: 7786606.