WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H529104
CAS#: 851518-71-3
Description: Hydronidone, also known as F-351, are Non-Steroidal Antiinflammatory Drugs (NSAIDs) potentially for the treatment of hepatic fibrosis.
Hodoodo Cat#: H529104
Name: Hydronidone
CAS#: 851518-71-3
Chemical Formula: C12H11NO2
Exact Mass: 201.08
Molecular Weight: 201.220
Elemental Analysis: C, 71.63; H, 5.51; N, 6.96; O, 15.90
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Synonym: F-351; F351; F 351
IUPAC/Chemical Name: 1-(4-hydroxyphenyl)-5-methylpyridin-2(1H)-one
InChi Key: NETTXQJYJRFTFS-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H11NO2/c1-9-2-7-12(15)13(8-9)10-3-5-11(14)6-4-10/h2-8,14H,1H3
SMILES Code: O=C1C=CC(C)=CN1C2=CC=C(O)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 201.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Liu Y, Wu J, Li Z, Luo Y, Zeng F, Shi S. Tolerability and Pharmacokinetics of
Hydronidone, an Antifibrotic Agent for Hepatic Fibrosis, after Single and
Multiple Doses in Healthy Subjects: an Open-Label, Randomized, Dose-Escalating,
First-in-Human Study. Eur J Drug Metab Pharmacokinet. 2017 Feb;42(1):37-48. doi:
10.1007/s13318-015-0316-z. PubMed PMID: 26797810.
