WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H528317
CAS#: 401789-93-3
Description: LY-510929, also known as LY-929, is a peroxisome proliferator-activated receptor (PPAR) agonist potentially for the treatment of hyperlipidaemia, metabolic disorders and type 2 diabetes.
Hodoodo Cat#: H528317
Name: LY-510929
CAS#: 401789-93-3
Chemical Formula: C26H25NO5S
Exact Mass: 463.15
Molecular Weight: 463.548
Elemental Analysis: C, 67.37; H, 5.44; N, 3.02; O, 17.26; S, 6.92
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Synonym: LY-510929; LY 510929; LY510929; LY-929; LY 929; LY929
IUPAC/Chemical Name: (S)-2-methyl-3-(4-(2-(5-methyl-2-(thiophen-2-yl)oxazol-4-yl)ethoxy)phenyl)-2-phenoxypropanoic acid
InChi Key: KWSPYUOBNIMILB-SANMLTNESA-N
InChi Code: InChI=1S/C26H25NO5S/c1-18-22(27-24(31-18)23-9-6-16-33-23)14-15-30-20-12-10-19(11-13-20)17-26(2,25(28)29)32-21-7-4-3-5-8-21/h3-13,16H,14-15,17H2,1-2H3,(H,28,29)/t26-/m0/s1
SMILES Code: CC(O1)=C(CCOC2=CC=C(C[C@@](OC3=CC=CC=C3)(C)C(O)=O)C=C2)N=C1C4=CC=CS4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 463.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Engle SK, Solter PF, Credille KM, Bull CM, Adams S, Berna MJ, Schultze AE, Rothstein EC, Cockman MD, Pritt ML, Liu H, Lu Y, Chiang AY, Watson DE. Detection of left ventricular hypertrophy in rats administered a peroxisome proliferator-activated receptor alpha/gamma dual agonist using natriuretic peptides and imaging. Toxicol Sci. 2010 Apr;114(2):183-92. doi: 10.1093/toxsci/kfp311. PubMed PMID: 20044590.
2: Xu Y, Rito CJ, Etgen GJ, Ardecky RJ, Bean JS, Bensch WR, Bosley JR, Broderick CL, Brooks DA, Dominianni SJ, Hahn PJ, Liu S, Mais DE, Montrose-Rafizadeh C, Ogilvie KM, Oldham BA, Peters M, Rungta DK, Shuker AJ, Stephenson GA, Tripp AE, Wilson SB, Winneroski LL, Zink R, Kauffman RF, McCarthy JR. Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists. J Med Chem. 2004 May 6;47(10):2422-5. PubMed PMID: 15115385.