WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H530539
CAS#: 71203-35-5
Description: ML-141, also known as CID2950007, is a Cdc42 inhibitor (EC50 = 2.1 µM).
Hodoodo Cat#: H530539
Name: ML-141
CAS#: 71203-35-5
Chemical Formula: C22H21N3O3S
Exact Mass: 407.13
Molecular Weight: 407.488
Elemental Analysis: C, 64.85; H, 5.19; N, 10.31; O, 11.78; S, 7.87
Synonym: ML-141; ML 141; ML141; CID2950007; CID-2950007; CID 2950007.
IUPAC/Chemical Name: 4-[4,5-dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide
InChi Key: QBNZBMVRFYREHK-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H21N3O3S/c1-28-19-11-7-17(8-12-19)22-15-21(16-5-3-2-4-6-16)24-25(22)18-9-13-20(14-10-18)29(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27)
SMILES Code: O=S(C1=CC=C(N2N=C(C3=CC=CC=C3)CC2C4=CC=C(OC)C=C4)C=C1)(N)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 407.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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2: Zhan Y, Liang X, Li L, Wang B, Ding F, Li Y, Wang X, Zhan Q, Liu Z. MicroRNA-548j functions as a metastasis promoter in human breast cancer by targeting Tensin1. Mol Oncol. 2016 Jun;10(6):838-49. doi: 10.1016/j.molonc.2016.02.002. PubMed PMID: 26949125.
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4: Guo Y, Kenney SR, Muller CY, Adams S, Rutledge T, Romero E, Murray-Krezan C, Prekeris R, Sklar LA, Hudson LG, Wandinger-Ness A. R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis. Mol Cancer Ther. 2015 Oct;14(10):2215-27. doi: 10.1158/1535-7163.MCT-15-0419. PubMed PMID: 26206334; PubMed Central PMCID: PMC4596774.
5: Cheng SL, Ramachandran B, Behrmann A, Shao JS, Mead M, Smith C, Krchma K, Bello Arredondo Y, Kovacs A, Kapoor K, Brill LM, Perera R, Williams BO, Towler DA. Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals. Circ Res. 2015 Jul 3;117(2):142-56. doi: 10.1161/CIRCRESAHA.117.306712. PubMed PMID: 26034040; PubMed Central PMCID: PMC4490945.
6: Ferru-Clément R, Fresquet F, Norez C, Métayé T, Becq F, Kitzis A, Thoreau V. Involvement of the Cdc42 pathway in CFTR post-translational turnover and in its plasma membrane stability in airway epithelial cells. PLoS One. 2015 Mar 13;10(3):e0118943. doi: 10.1371/journal.pone.0118943. PubMed PMID: 25768293; PubMed Central PMCID: PMC4359135.
7: Zhang Y, Liu J, Luan G, Wang X. Inhibition of the small GTPase Cdc42 in regulation of epileptic-seizure in rats. Neuroscience. 2015 Mar 19;289:381-91. doi: 10.1016/j.neuroscience.2014.12.059. PubMed PMID: 25595978.
8: Hsu CR, Pan YJ, Liu JY, Chen CT, Lin TL, Wang JT. Klebsiella pneumoniae translocates across the intestinal epithelium via Rho GTPase- and phosphatidylinositol 3-kinase/Akt-dependent cell invasion. Infect Immun. 2015 Feb;83(2):769-79. doi: 10.1128/IAI.02345-14. PubMed PMID: 25452552; PubMed Central PMCID: PMC4294243.
9: Kumar A, Al-Sammarraie N, DiPette DJ, Singh US. Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma. Oncotarget. 2014 Nov 30;5(22):11709-22. PubMed PMID: 25365944; PubMed Central PMCID: PMC4294363.
10: Antolín AA, Mestres J. Distant polypharmacology among MLP chemical probes. ACS Chem Biol. 2015 Feb 20;10(2):395-400. doi: 10.1021/cb500393m. PubMed PMID: 25365788.
11: Chen C, Song X, Ma S, Wang X, Xu J, Zhang H, Wu Q, Zhao K, Cao J, Qiao J, Sun X, Li D, Zeng L, Li Z, Xu K. Cdc42 inhibitor ML141 enhances G-CSF-induced hematopoietic stem and progenitor cell mobilization. Int J Hematol. 2015 Jan;101(1):5-12. doi: 10.1007/s12185-014-1690-z. PubMed PMID: 25315193.
12: Weinberg MS, Nicolson S, Bhatt AP, McLendon M, Li C, Samulski RJ. Recombinant adeno-associated virus utilizes cell-specific infectious entry mechanisms. J Virol. 2014 Nov;88(21):12472-84. doi: 10.1128/JVI.01971-14. PubMed PMID: 25142580; PubMed Central PMCID: PMC4248914.
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14: McNary SM, Athanasiou KA, Reddi AH. Transforming growth factor β-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton. Tissue Eng Part A. 2014 Mar;20(5-6):921-9. doi: 10.1089/ten.TEA.2013.0043. PubMed PMID: 24116978; PubMed Central PMCID: PMC3938930.
15: Chen HY, Yang YM, Stevens BM, Noble M. Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells. EMBO Mol Med. 2013 May;5(5):723-36. doi: 10.1002/emmm.201202140. PubMed PMID: 23606532; PubMed Central PMCID: PMC3662315.
16: Surviladze Z, Waller A, Strouse JJ, Bologa C, Ursu O, Salas V, Parkinson JF, Phillips GK, Romero E, Wandinger-Ness A, Sklar LA, Schroeder C, Simpson D, Nöth J, Wang J, Golden J, Aubé J. A Potent and Selective Inhibitor of Cdc42 GTPase. 2010 Feb 27 [updated 2010 Dec 16]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK51965/ PubMed PMID: 21433396.