WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H532184
CAS#: 459168-97-9
Description: MJN228 is a selective ligand for the lipid-binding protein nucleobindin 1 (NUCB1), blocking binding of the probe arachidonoyl ethanolamide-diazirine with an IC50 value of 3.3 µM. It prevents probe binding to NUCB1 in Neuro2a cells at concentrations as low as 10 µM.
Hodoodo Cat#: H532184
Name: MJN228
CAS#: 459168-97-9
Chemical Formula: C20H20N4O3
Exact Mass: 364.15
Molecular Weight: 364.405
Elemental Analysis: C, 65.92; H, 5.53; N, 15.38; O, 13.17
Synonym: MJN228; MJN 228; MJN-228.
IUPAC/Chemical Name: (4-methylpiperazin-1-yl)-(5-nitro-3-phenyl-1H-indol-2-yl)methanone
InChi Key: BLSWPPPBUQFKHH-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H20N4O3/c1-22-9-11-23(12-10-22)20(25)19-18(14-5-3-2-4-6-14)16-13-15(24(26)27)7-8-17(16)21-19/h2-8,13,21H,9-12H2,1H3
SMILES Code: O=C(N1CCN(C)CC1)C(N2)=C(C3=CC=CC=C3)C4=C2C=CC([N+]([O-])=O)=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 364.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. M. J. Niphakis, K. M. Lum, A. B. Cognetta, III, et al. A global map of the lipid-binding proteins and their ligandability in cells. Cell 161, 1668-1680 (2015).