MRS1191
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H532275

CAS#: 185222-90-6

Description: MRS1191 is a selective A3 adenosine receptor antagonist.

Chemical Structure

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MRS1191
CAS# 185222-90-6
Instruction

Theoretical Analysis

Hodoodo Cat#: H532275
Name: MRS1191
CAS#: 185222-90-6
Chemical Formula: C31H27NO4
Exact Mass: 477.19
Molecular Weight: 477.560
Elemental Analysis: C, 77.97; H, 5.70; N, 2.93; O, 13.40

Price and Availability

Size Price Availability Quantity
2mg USD 530
5mg USD 1100
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Synonym: MRS1191; MRS 1191; MRS-1191.

IUPAC/Chemical Name: O3-ethyl O5-(phenylmethyl) 2-methyl-6-phenyl-4-(2-phenylethynyl)-1,4-dihydropyridine-3,5-dicarboxylate

InChi Key: SNVFDPHQAOXWJZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C31H27NO4/c1-3-35-30(33)27-22(2)32-29(25-17-11-6-12-18-25)28(26(27)20-19-23-13-7-4-8-14-23)31(34)36-21-24-15-9-5-10-16-24/h4-18,26,32H,3,21H2,1-2H3

SMILES Code: O=C(C1=C(C)NC(C2=CC=CC=C2)=C(C(OCC3=CC=CC=C3)=O)C1C#CC4=CC=CC=C4)OCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 477.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Nagaya H, Gotoh A, Kanno T, Nishizaki T. A3 adenosine receptor mediates apoptosis in in vitro RCC4-VHL human renal cancer cells by up-regulating AMID expression. J Urol. 2013 Jan;189(1):321-8. doi: 10.1016/j.juro.2012.08.193. PubMed PMID: 23174235.

2: Kanno T, Gotoh A, Fujita Y, Nakano T, Nishizaki T. A(3) adenosine receptor mediates apoptosis in 5637 human bladder cancer cells by G(q) protein/PKC-dependent AIF upregulation. Cell Physiol Biochem. 2012;30(5):1159-68. doi: 10.1159/000343306. PubMed PMID: 23171836.

3: Kim TH, Kim YK, Woo JS. The adenosine A3 receptor agonist Cl-IB-MECA induces cell death through Ca²⁺/ROS-dependent down regulation of ERK and Akt in A172 human glioma cells. Neurochem Res. 2012 Dec;37(12):2667-77. doi: 10.1007/s11064-012-0855-5. PubMed PMID: 22878643.