WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H528526
CAS#: 93118-77-5
Description: UK-52831 is a calcium channel antagonist potentially for the treatment of hypertension and myocardia ischemia. UK-52,831 emerged as a potent (IC50 = 6.3 X 10(-9) M) and tissue-selective calcium channel blocker with a duration of action greater than 7 h in the anaesthetized dog.
Hodoodo Cat#: H528526
Name: UK-52831
CAS#: 93118-77-5
Chemical Formula: C22H26Cl2N6O5
Exact Mass: 524.13
Molecular Weight: 525.387
Elemental Analysis: C, 50.29; H, 4.99; Cl, 13.49; N, 16.00; O, 15.23
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Related CAS #: 93118-77-5,
Synonym: UK-52831, UK 52831, UK52831; UK-52,831; UK 52,831; UK52,831;
IUPAC/Chemical Name: 3-Ethyl 5-methyl 2-[[2-[(3-amino-1H-1,2,4-triazol-5-yl)amino]ethoxy]methyl]-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
InChi Key: LECRJMNEIPCUSK-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H26Cl2N6O5/c1-4-35-20(32)17-14(10-34-9-8-26-22-28-21(25)29-30-22)27-11(2)15(19(31)33-3)16(17)12-6-5-7-13(23)18(12)24/h5-7,16,27H,4,8-10H2,1-3H3,(H4,25,26,28,29,30)
SMILES Code: O=C(C1=C(COCCNC2=NC(N)=NN2)NC(C)=C(C(OC)=O)C1C3=CC=CC(Cl)=C3Cl)OCC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 525.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Arrowsmith JE, Campbell SF, Cross PE, Burges RA, Gardiner DG. Long acting dihydropyridine calcium antagonists. 2. 2-[2-Aminoheterocycloethoxy]methyl derivatives. J Med Chem. 1989 Mar;32(3):562-8. doi: 10.1021/jm00123a009. PMID: 2918502.