WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H407438
CAS#: 1005264-47-0
Description: MX69 is a Dual Inhibitor of MDM2 and XIAP for Cancer Treatment.
Hodoodo Cat#: H407438
Name: MX69
CAS#: 1005264-47-0
Chemical Formula: C27H26N2O4S
Exact Mass: 474.16
Molecular Weight: 474.575
Elemental Analysis: C, 68.33; H, 5.52; N, 5.90; O, 13.48; S, 6.76
Synonym: MX69; MX-69; MX 69.
IUPAC/Chemical Name: 4-(8-(N-(2,3-dimethylphenyl)sulfamoyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl)benzoic acid
InChi Key: LAISWEODQAOXGJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H26N2O4S/c1-16-5-3-8-24(17(16)2)29-34(32,33)20-13-14-25-23(15-20)21-6-4-7-22(21)26(28-25)18-9-11-19(12-10-18)27(30)31/h3-6,8-15,21-22,26,28-29H,7H2,1-2H3,(H,30,31)
SMILES Code: O=S(C1=CC2=C(NC(C3=CC=C(C(O)=O)C=C3)C4C2C=CC4)C=C1)(NC5=C(C)C(C)=CC=C5)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 474.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Gu L, Zhang H, Liu T, Zhou S, Du Y, Xiong J, Yi S, Qu CK, Fu H, Zhou M.
Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer Cell.
2016 Oct 10;30(4):623-636. doi: 10.1016/j.ccell.2016.08.015. Epub 2016 Sep 22.
PubMed PMID: 27666947; PubMed Central PMCID: PMC5079537.