WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H532485
CAS#: 24003-58-5
Description: QX-314 Br is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels. QX 314 bromide also inhibits calcium currents in hippocampal CA1 pyramidal neurons.
Hodoodo Cat#: H532485
Name: QX-314 Br
CAS#: 24003-58-5
Chemical Formula: C16H27BrN2O
Exact Mass: 0.00
Molecular Weight: 343.310
Elemental Analysis: C, 55.98; H, 7.93; Br, 23.27; N, 8.16; O, 4.66
Related CAS #: 24003-58-5 (QX-314 Br); 21306-56-9 (QX-314); 5369-03-9 (QX-314 HCl).
Synonym: QX-314 Br; QX-314Br; QX314 Br; QX 314; QX314.
IUPAC/Chemical Name: N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide
InChi Key: DLHMKHREUTXMCH-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
SMILES Code: CC[N+](CC)(CC(NC1=C(C)C=CC=C1C)=O)CC.[Br-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 343.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Talbot and Sayer (1996) Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. J.Neurophysiol. 76 2120. PMID: 8890325.
2. Perkins and Wong (1995) Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells. J.Neurophysiol. 73 911. PMID: 7760149.