WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H532860
CAS#: 201147-53-7
Description: UCL-1848 trifluoroacetate salt is a selective Ca2+-activated, SK potassium channel blocker.
Hodoodo Cat#: H532860
Name: UCL-1848 trifluoroacetate salt
CAS#: 201147-53-7
Chemical Formula: C28H34N42+
Exact Mass: 426.28
Molecular Weight: 426.610
Elemental Analysis: C, 78.83; H, 8.03; N, 13.13
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Synonym: UCL1848, UCL-1848, UCL 1848, UCL-1848 trifluoroacetate salt
IUPAC/Chemical Name: 8,14-Diaza-1,7(1,4)-diquinolinacyclotetradecaphane trifluoroacetate salt
InChi Key: IOXVWOJJNCBJBX-XDHTVYJESA-P
InChi Code: InChI=1S/C28H32N4/c1-7-17-29-25-15-21-31(27-13-5-3-11-23(25)27)19-9-2-10-20-32-22-16-26(30-18-8-1)24-12-4-6-14-28(24)32/h3-6,11-16,21-22H,1-2,7-10,17-20H2/p+2/b29-25+,30-26+
SMILES Code: c1(NCCCCCNc2c(cccc3)c3[n+]4cc2)c5ccccc5[n+](CCCCC4)cc1
Appearance: White to off-white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 426.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Abdullaev IF, Rudkouskaya A, Mongin AA, Kuo YH. Calcium-activated potassium channels BK and IK1 are functionally expressed in human gliomas but do not regulate cell proliferation. PLoS One. 2010 Aug 20;5(8):e12304. doi: 10.1371/journal.pone.0012304. PubMed PMID: 20808839; PubMed Central PMCID: PMC2924897.
2: Lopez de Armentia M, Sah P. Firing properties and connectivity of neurons in the rat lateral central nucleus of the amygdala. J Neurophysiol. 2004 Sep;92(3):1285-94. Epub 2004 May 5. PubMed PMID: 15128752.
3: Faber ES, Sah P. Physiological role of calcium-activated potassium currents in the rat lateral amygdala. J Neurosci. 2002 Mar 1;22(5):1618-28. PubMed PMID: 11880492.
4: Shah M, Haylett DG. The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. Br J Pharmacol. 2000 Feb;129(4):627-30. PubMed PMID: 10683185; PubMed Central PMCID: PMC1571896.