WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H532960
CAS#: 307002-73-9
Description: WAY170523 is a selective and potent inhibitor of MMP-13(IC50 values are 17, 945, > 1000 and > 10000 nM for MMP-13, MMP-9, TACE and MMP-1 respectively). MMPs (matrix metalloproteinases) are commonly known to be involved in the degradation of various extracellular matrix proteins.
Hodoodo Cat#: H532960
Name: WAY170523
CAS#: 307002-73-9
Chemical Formula: C33H31N3O7S
Exact Mass: 613.19
Molecular Weight: 613.690
Elemental Analysis: C, 64.59; H, 5.09; N, 6.85; O, 18.25; S, 5.22
Synonym: WAY170523; WAY-170523; WAY 170523
IUPAC/Chemical Name: N-[2-(4-{benzyl[2-(hydroxycarbamoyl)-4,6-dimethylphenyl]sulfamoyl}phenoxy)ethyl]-1-benzofuran-2-carboxamide
InChi Key: FARMEEAGJWMFSZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C33H31N3O7S/c1-22-18-23(2)31(28(19-22)32(37)35-39)36(21-24-8-4-3-5-9-24)44(40,41)27-14-12-26(13-15-27)42-17-16-34-33(38)30-20-25-10-6-7-11-29(25)43-30/h3-15,18-20,39H,16-17,21H2,1-2H3,(H,34,38)(H,35,37)
SMILES Code: O=C(C(O1)=CC2=C1C=CC=C2)NCCOC3=CC=C(S(=O)(N(CC4=CC=CC=C4)C5=C(C)C=C(C)C=C5C(NO)=O)=O)C=C3
Appearance: White to beige solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 613.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Jaffré et al (2012) ß-adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells. Circulation 125 2993. PMID: 22610965.
