WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H532962
CAS#: 872002-73-8
Description: WAY 207024 dihydrochloride is a gonadotropin releasing hormone receptor (GnRH-R) antagonist. WAY 207024 dihydrochloride exhibits potent affinity (IC50 values are 12 and 71 nM for human and rat GnRH receptors respectively).
Hodoodo Cat#: H532962
Name: WAY 207024 dihydrochloride
CAS#: 872002-73-8
Chemical Formula: C30H34Cl2N6
Exact Mass: 0.00
Molecular Weight: 549.540
Elemental Analysis: C, 65.57; H, 6.24; Cl, 12.90; N, 15.29
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Related CAS #: 872002-73-8 (2HCl) 872002-72-7 (free)
Synonym: WAY-207024 ; WAY 207024 ; WAY207024; WAY 207024 dihydrochloride; WAY 207024 diHCl.
IUPAC/Chemical Name: 6-((4-(2-(4-(tert-butyl)phenyl)-1H-benzo[d]imidazol-4-yl)piperazin-1-yl)methyl)quinoxaline dihydrochloride
InChi Key: REQCNTGYEABOIT-UHFFFAOYSA-N
InChi Code: InChI=1S/C30H32N6.2ClH/c1-30(2,3)23-10-8-22(9-11-23)29-33-25-5-4-6-27(28(25)34-29)36-17-15-35(16-18-36)20-21-7-12-24-26(19-21)32-14-13-31-24;;/h4-14,19H,15-18,20H2,1-3H3,(H,33,34);2*1H
SMILES Code: CC(C1=CC=C(C2=NC3=C(N4CCN(CC5=CC=C6N=CC=NC6=C5)CC4)C=CC=C3N2)C=C1)(C)C.[H]Cl.[H]Cl
Appearance: White to off-white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 549.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Pelletier JC, Chengalvala MV, Cottom JE, Feingold IB, Green DM, Hauze DB, Huselton CA, Jetter JW, Kopf GS, Lundquist JT, Magolda RL, Mann CW, Mehlmann JF, Rogers JF, Shanno LK, Adams WR, Tio CO, Wrobel JE. Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxal ine (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). J Med Chem. 2009 Apr 9;52(7):2148-52. doi: 10.1021/jm801572m. PubMed PMID: 19271735.