DYRKi

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H525865

CAS#: 1640364-04-0

Description: DYRKi is a novel nontoxic and selective DYRK1 inhibitor.

Chemical Structure

img
DYRKi
CAS# 1640364-04-0
Instruction

Theoretical Analysis

Hodoodo Cat#: H525865
Name: DYRKi
CAS#: 1640364-04-0
Chemical Formula: C20H13F3N4O2S
Exact Mass: 430.07
Molecular Weight: 430.405
Elemental Analysis: C, 55.81; H, 3.04; F, 13.24; N, 13.02; O, 7.43; S, 7.45

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: DYRKi

IUPAC/Chemical Name: 2-(2,3-Dihydro-benzofuran-5-yl)-thiazole-4-carboxylic acid (5-trifluoromethyl-1H-benzoimidazol-2-yl)-amide

InChi Key: IINDNGLKYISGRR-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H13F3N4O2S/c21-20(22,23)12-2-3-13-14(8-12)26-19(25-13)27-17(28)15-9-30-18(24-15)11-1-4-16-10(7-11)5-6-29-16/h1-4,7-9H,5-6H2,(H2,25,26,27,28)

SMILES Code: O=C(C1=CSC(C2=CC=C(OCC3)C3=C2)=N1)NC4=NC5=CC(C(F)(F)F)=CC=C5N4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 430.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Peromaa-Haavisto P, Tuomilehto H, Kössi J, Virtanen J, Luostarinen M, Pihlajamäki J, Käkelä P, Victorzon M. Obstructive sleep apnea: the effect of bariatric surgery after 12 months. A prospective multicenter trial. Sleep Med. 2017 Jan 12. pii: S1389-9457(17)30004-7. doi: 10.1016/j.sleep.2016.12.017. [Epub ahead of print] PubMed PMID: 28549834.

2: Ferreira ARV, Haapanen J, Mäkelä JM, Bratvold JE, Nilsen O, Tuominen M, Alves VD, Coelhoso IM. Comparison of different coating techniques on the properties of FucoPol films. Int J Biol Macromol. 2017 May 10;103:268-274. doi: 10.1016/j.ijbiomac.2017.05.021. [Epub ahead of print] PubMed PMID: 28499944.

3: Ristolainen L, Kettunen JA, Kujala UM, Heinonen A, Schlenzka D. Progression of untreated mild thoracic Scheuermann's kyphosis - Radiographic and functional assessment after mean follow-up of 46 years. J Orthop Sci. 2017 Apr 15. pii: S0949-2658(17)30077-5. doi: 10.1016/j.jos.2017.03.009. [Epub ahead of print] PubMed PMID: 28420562.

4: Ylilauri MP, Voutilainen S, Lönnroos E, Mursu J, Virtanen HE, Koskinen TT, Salonen JT, Tuomainen TP, Virtanen JK. Association of dietary cholesterol and egg intakes with the risk of incident dementia or Alzheimer disease: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr. 2017 Feb;105(2):476-484. doi: 10.3945/ajcn.116.146753. Epub 2017 Jan 4. PubMed PMID: 28052883.

5: Jin C, Viidanoja J. Determination of glycerol in oils and fats using liquid chromatography chloride attachment electrospray ionization mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 15;1041-1042:94-97. doi: 10.1016/j.jchromb.2016.11.041. Epub 2016 Dec 15. PubMed PMID: 28013180.

6: Viidanoja J. Quantification of short chain amines in aqueous matrices using liquid chromatography electrospray ionization tandem mass spectrometry. J Chromatogr A. 2017 Jan 13;1480:106-111. doi: 10.1016/j.chroma.2016.12.037. Epub 2016 Dec 15. PubMed PMID: 27993393.

7: Kukkonen JP. Orexin/Hypocretin Signaling. Curr Top Behav Neurosci. 2016 Dec 2. doi: 10.1007/7854_2016_49. [Epub ahead of print] PubMed PMID: 27909990.

8: Semjonov K, Kogermann K, Laidmäe I, Antikainen O, Strachan CJ, Ehlers H, Yliruusi J, Heinämäki J. The formation and physical stability of two-phase solid dispersion systems of indomethacin in supercooled molten mixtures with different matrix formers. Eur J Pharm Sci. 2017 Jan 15;97:237-246. doi: 10.1016/j.ejps.2016.11.019. Epub 2016 Nov 24. PubMed PMID: 27890595.

9: Kattipparambil Rajan D, Patrikoski M, Verho J, Sivula J, Ihalainen H, Miettinen S, Lekkala J. Optical non-contact pH measurement in cell culture with sterilizable, modular parts. Talanta. 2016 Dec 1;161:755-761. doi: 10.1016/j.talanta.2016.09.021. Epub 2016 Sep 8. PubMed PMID: 27769477.

10: Niemi M, Rolandsen CM, Neumann W, Kukko T, Tiilikainen R, Pusenius J, Solberg EJ, Ericsson G. Temporal patterns of moose-vehicle collisions with and without personal injuries. Accid Anal Prev. 2017 Jan;98:167-173. doi: 10.1016/j.aap.2016.09.024. Epub 2016 Oct 8. PubMed PMID: 27723518.

11: Ahveninen J, Chang WT, Huang S, Keil B, Kopco N, Rossi S, Bonmassar G, Witzel T, Polimeni JR. Intracortical depth analyses of frequency-sensitive regions of human auditory cortex using 7TfMRI. Neuroimage. 2016 Dec;143:116-127. doi: 10.1016/j.neuroimage.2016.09.010. Epub 2016 Sep 5. PubMed PMID: 27608603; PubMed Central PMCID: PMC5124525.

12: Tajik B, Kurl S, Tuomainen TP, Virtanen JK. Associations of the serum long-chain omega-3 polyunsaturated fatty acids and hair mercury with heart rate-corrected QT and JT intervals in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Eur J Nutr. 2016 Jul 18. [Epub ahead of print] PubMed PMID: 27431893.

13: Salmela M, Rappu P, Lilja J, Niskanen H, Taipalus E, Jokinen J, Heino J. Tumor promoter PMA enhances kindlin-2 and decreases vimentin recruitment into cell adhesion sites. Int J Biochem Cell Biol. 2016 Sep;78:22-30. doi: 10.1016/j.biocel.2016.06.017. Epub 2016 Jun 29. PubMed PMID: 27373681.

14: Kukkonen JP. G-protein-dependency of orexin/hypocretin receptor signalling in recombinant Chinese hamster ovary cells. Biochem Biophys Res Commun. 2016 Aug 5;476(4):379-85. doi: 10.1016/j.bbrc.2016.05.130. Epub 2016 May 26. PubMed PMID: 27237973.

15: Yary T, Voutilainen S, Tuomainen TP, Ruusunen A, Nurmi T, Virtanen JK. Serum n-6 polyunsaturated fatty acids, Δ5- and Δ6-desaturase activities, and risk of incident type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr. 2016 May;103(5):1337-43. doi: 10.3945/ajcn.115.128629. Epub 2016 Mar 23. PubMed PMID: 27009754.

16: Virtanen JK, Mursu J, Virtanen HE, Fogelholm M, Salonen JT, Koskinen TT, Voutilainen S, Tuomainen TP. Associations of egg and cholesterol intakes with carotid intima-media thickness and risk of incident coronary artery disease according to apolipoprotein E phenotype in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr. 2016 Mar;103(3):895-901. doi: 10.3945/ajcn.115.122317. Epub 2016 Feb 10. PubMed PMID: 26864369.

17: Tonteri E, Jokelainen P, Matala J, Pusenius J, Vapalahti O. Serological evidence of tick-borne encephalitis virus infection in moose and deer in Finland: sentinels for virus circulation. Parasit Vectors. 2016 Jan 29;9:54. doi: 10.1186/s13071-016-1335-6. PubMed PMID: 26825371; PubMed Central PMCID: PMC4733276.

18: Rakkolainen I, Vuola J. Plasma NGAL predicts early acute kidney injury no earlier than s-creatinine or cystatin C in severely burned patients. Burns. 2016 Mar;42(2):322-8. doi: 10.1016/j.burns.2015.11.006. Epub 2015 Dec 24. PubMed PMID: 26724852.

19: Kukkonen JP. G-protein inhibition profile of the reported Gq/11 inhibitor UBO-QIC. Biochem Biophys Res Commun. 2016 Jan 1;469(1):101-7. doi: 10.1016/j.bbrc.2015.11.078. Epub 2015 Nov 22. PubMed PMID: 26614908.

20: Kukkonen JP. OX2 orexin/hypocretin receptor signal transduction in recombinant Chinese hamster ovary cells. Cell Signal. 2016 Feb;28(2):51-60. doi: 10.1016/j.cellsig.2015.11.009. Epub 2015 Nov 12. PubMed PMID: 26582739.