WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H532977
CAS#: 725247-18-7
Description: XCT790 is a selective ERRα antagonist/inverse agonist (IC50 = ~400 nM). XCT790 displays no antagonist activity at ERRγ or ERα at concentrations below 10 μM. It interferes with PPARγ coactivator-1α (PGC-1α)/ERRα-dependent signaling.
Hodoodo Cat#: H532977
Name: XCT790
CAS#: 725247-18-7
Chemical Formula: C23H13F9N4O3S
Exact Mass: 596.06
Molecular Weight: 596.430
Elemental Analysis: C, 46.32; H, 2.20; F, 28.67; N, 9.39; O, 8.05; S, 5.38
Synonym: XCT790; XCT 790; XCT-790.
IUPAC/Chemical Name: (E)-3-[4-[[2, 4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5- (trifluoromethyl)-1,3,4-thiadiazol-2-yl]prop-2-enamide
InChi Key: HQFNFOOGGLSBBT-AWNIVKPZSA-N
InChi Code: InChI=1S/C23H13F9N4O3S/c1-38-17-7-11(6-13(9-33)18(37)34-20-36-35-19(40-20)23(30,31)32)2-5-16(17)39-10-12-3-4-14(21(24,25)26)8-15(12)22(27,28)29/h2-8H,10H2,1H3,(H,34,36,37)/b13-6+
SMILES Code: O=C(NC1=NN=C(C(F)(F)F)S1)/C(C#N)=C/C2=CC=C(OCC3=CC=C(C(F)(F)F)C=C3C(F)(F)F)C(OC)=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 596.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Lu YH, Li QY, Chen L, Shi XJ. [XCT790 inhibits rat vascular smooth muscle cells proliferation through down-regulating the expression of estrogen-related receptor alpha]. Yao Xue Xue Bao. 2014 Feb;49(2):190-7. Chinese. PubMed PMID: 24761608.
2: Lanvin O, Bianco S, Kersual N, Chalbos D, Vanacker JM. Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-alpha inverse agonist XCT790. J Biol Chem. 2007 Sep 28;282(39):28328-34. Epub 2007 Jul 12. PubMed PMID: 17631492.