WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526115
CAS#: 107019-95-4
Description: Hymenidin is a natural antagonist of serotonergic receptors and inhibitor of CDK5/p25 and GSK-3ß.
Hodoodo Cat#: H526115
Name: Hymenidin
CAS#: 107019-95-4
Chemical Formula: C11H12BrN5O
Exact Mass: 309.02
Molecular Weight: 310.155
Elemental Analysis: C, 42.60; H, 3.90; Br, 25.76; N, 22.58; O, 5.16
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Synonym: Hymenidin
IUPAC/Chemical Name: N-[(E)-3-(2-Amino-1H-imidazol-5-yl)prop-2-enyl]-4-bromo-1H-pyrrole-2-carboxamide
InChi Key: KHJREOQCERRAME-OWOJBTEDSA-N
InChi Code: InChI=1S/C11H12BrN5O/c12-7-4-9(15-5-7)10(18)14-3-1-2-8-6-16-11(13)17-8/h1-2,4-6,15H,3H2,(H,14,18)(H3,13,16,17)/b2-1+
SMILES Code: O=C(C1=CC(Br)=CN1)NC/C=C/C2=CN=C(N)N2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 310.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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3: Rasapalli S, Kumbam V, Dhawane AN, Golen JA, Lovely CJ, Rheingold AL. Total syntheses of oroidin, hymenidin and clathrodin. Org Biomol Chem. 2013 Jul 7;11(25):4133-7. doi: 10.1039/c3ob40668g. PubMed PMID: 23695419.
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5: Medeiros MA, Lourenço A, Tavares MR, Curto MJ, Feio SS, Roseiro JC. (-)-Agelasidine A from Agelas clathrodes. Z Naturforsch C. 2006 Jul-Aug;61(7-8):472-6. PubMed PMID: 16989304.
6: Pettit GR, Ducki S, Herald DL, Doubek DL, Schmidt JM, Chapuis JC. Antineoplastic agents 470. Absolute configuration of the marine sponge bromopyrrole agelastatin A. Oncol Res. 2005;15(1):11-20. PubMed PMID: 15839302.
7: Bickmeyer U, Drechsler C, Köck M, Assmann M. Brominated pyrrole alkaloids from marine Agelas sponges reduce depolarization-induced cellular calcium elevation. Toxicon. 2004 Jul;44(1):45-51. PubMed PMID: 15225561.
8: Assmann M, Zea S, Köck M. Sventrin, a new bromopyrrole alkaloid from the Caribbean sponge Agelas sventres. J Nat Prod. 2001 Dec;64(12):1593-5. PubMed PMID: 11754625.
9: Kobayashi J, Ohizumi Y, Nakamura H, Hirata Y. A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp. Experientia. 1986 Oct 15;42(10):1176-7. PubMed PMID: 3770140.