WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H540170
CAS#: 52286-59-6
Description: Ginsenoside Re is a PPARγ agonist found in species of Panax. It inhibis formation of gastric mucosal lesions, decreases neutrophil infiltration, stimulates CD4+ T cell production, suppresses histamine release in mast cells, and prevents stress-induced anxiety, depression and cognitive deficits.
Hodoodo Cat#: H540170
Name: Ginsenoside Re
CAS#: 52286-59-6
Chemical Formula: C48H82O18
Exact Mass: 946.55
Molecular Weight: 947.160
Elemental Analysis: C, 60.87; H, 8.73; O, 30.40
Synonym: Ginsenoside B2; Ginsenoside RE; NSC 308877; NSC-308877; NSC308877; Panaxoside RE
IUPAC/Chemical Name: (2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-2-(((6R,8R,9R,10R,12S,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-((S)-6-methyl-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hept-5-en-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-6-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
InChi Key: PWAOOJDMFUQOKB-QVURTQSMSA-N
InChi Code: InChI=1S/C48H82O18/c1-21(2)11-10-14-48(9,66-42-38(60)35(57)32(54)26(19-49)63-42)23-12-16-46(7)30(23)24(51)17-28-45(6)15-13-29(52)44(4,5)40(45)25(18-47(28,46)8)62-43-39(36(58)33(55)27(20-50)64-43)65-41-37(59)34(56)31(53)22(3)61-41/h11,22-43,49-60H,10,12-20H2,1-9H3/t22-,23-,24-,25+,26+,27+,28+,29?,30-,31-,32+,33+,34+,35-,36-,37+,38+,39+,40?,41-,42-,43+,45+,46+,47+,48-/m0/s1
SMILES Code: O[C@@H]([C@@H]([C@@H](CO)O1)O)[C@@H](O[C@H]2[C@@H]([C@@H]([C@H]([C@H](C)O2)O)O)O)[C@@H]1O[C@H]3C4C(C)(C)C(O)CC[C@]4(C)[C@@]5([H])C[C@H](O)[C@]6([H])[C@@H]([C@@](C)(O[C@H]7[C@@H]([C@H]([C@@H]([C@@H](CO)O7)O)O)O)CC/C=C(C)\C)CC[C@](C)6[C@@](C)5C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 947.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Nam Y, Wie MB, Shin EJ, Nguyen TT, Nah SY, Ko SK, Jeong JH, Jang CG, Kim HC. Ginsenoside Re protects methamphetamine-induced mitochondrial burdens and proapoptosis via genetic inhibition of protein kinase C δ in human neuroblastoma dopaminergic SH-SY5Y cell lines. J Appl Toxicol. 2015 Aug;35(8):927-44. doi: 10.1002/jat.3093. Epub 2014 Dec 18. PubMed PMID: 25523949.
2: Qu H, Sai J, Wang Y, Sun Y, Zhang Y, Li Y, Zhao Y, Wang Q. Establishment of an enzyme-linked immunosorbent assay and application on determination of ginsenoside Re in human saliva. Planta Med. 2014 Aug;80(13):1143-50. doi: 10.1055/s-0034-1382959. Epub 2014 Sep 8. PubMed PMID: 25197955.
3: Sukrittanon S, Watanapa WB, Ruamyod K. Ginsenoside Re enhances small-conductance Ca(2+)-activated K(+) current in human coronary artery endothelial cells. Life Sci. 2014 Oct 12;115(1-2):15-21. doi: 10.1016/j.lfs.2014.09.007. Epub 2014 Sep 19. PubMed PMID: 25242515.
4: Wang L, Yuan D, Zhang D, Zhang W, Liu C, Cheng H, Song Y, Tan Q. Ginsenoside Re Promotes Nerve Regeneration by Facilitating the Proliferation, Differentiation and Migration of Schwann Cells via the ERK- and JNK-Dependent Pathway in Rat Model of Sciatic Nerve Crush Injury. Cell Mol Neurobiol. 2015 Aug;35(6):827-40. doi: 10.1007/s10571-015-0177-7. Epub 2015 Mar 17. PubMed PMID: 25776135.
5: Jang HJ, Han IH, Kim YJ, Yamabe N, Lee D, Hwang GS, Oh M, Choi KC, Kim SN, Ham J, Eom DW, Kang KS. Anticarcinogenic effects of products of heat-processed ginsenoside Re, a major constituent of ginseng berry, on human gastric cancer cells. J Agric Food Chem. 2014 Apr 2;62(13):2830-6. doi: 10.1021/jf5000776. Epub 2014 Mar 25. PubMed PMID: 24666263.
6: Park CM, Kim HM, Kim DH, Han HJ, Noh H, Jang JH, Park SH, Chae HJ, Chae SW, Ryu EK, Lee S, Liu K, Liu H, Ahn JS, Kim YO, Kim BY, Soung NK. Ginsenoside Re Inhibits Osteoclast Differentiation in Mouse Bone Marrow-Derived Macrophages and Zebrafish Scale Model. Mol Cells. 2016 Dec;39(12):855-861. doi: 10.14348/molcells.2016.0111. Epub 2016 Dec 6. PubMed PMID: 27927007; PubMed Central PMCID: PMC5223102.
7: Shin EJ, Shin SW, Nguyen TT, Park DH, Wie MB, Jang CG, Nah SY, Yang BW, Ko SK, Nabeshima T, Kim HC. Ginsenoside Re rescues methamphetamine-induced oxidative damage, mitochondrial dysfunction, microglial activation, and dopaminergic degeneration by inhibiting the protein kinase Cδ gene. Mol Neurobiol. 2014 Jun;49(3):1400-21. doi: 10.1007/s12035-013-8617-1. Epub 2014 Jan 16. PubMed PMID: 24430743.
8: Lee S, Kim MG, Ko SK, Kim HK, Leem KH, Kim YJ. Protective effect of ginsenoside Re on acute gastric mucosal lesion induced by compound 48/80. J Ginseng Res. 2014 Apr;38(2):89-96. doi: 10.1016/j.jgr.2013.10.001. Epub 2013 Dec 18. PubMed PMID: 24748832; PubMed Central PMCID: PMC3986637.
9: Kim JH, Han IH, Yamabe N, Kim YJ, Lee W, Eom DW, Choi P, Cheon GJ, Jang HJ, Kim SN, Ham J, Kang KS. Renoprotective effects of Maillard reaction products generated during heat treatment of ginsenoside Re with leucine. Food Chem. 2014 Jan 15;143:114-21. doi: 10.1016/j.foodchem.2013.07.075. Epub 2013 Jul 27. PubMed PMID: 24054220.
10: Su X, Pei Z, Hu S. Ginsenoside Re as an adjuvant to enhance the immune response to the inactivated rabies virus vaccine in mice. Int Immunopharmacol. 2014 Jun;20(2):283-9. doi: 10.1016/j.intimp.2014.03.008. Epub 2014 Mar 25. PubMed PMID: 24680943.
11: Cao G, Su P, Zhang S, Guo L, Zhang H, Liang Y, Qin C, Zhang W. Ginsenoside Re reduces Aβ production by activating PPARγ to inhibit BACE1 in N2a/APP695 cells. Eur J Pharmacol. 2016 Dec 15;793:101-108. doi: 10.1016/j.ejphar.2016.11.006. Epub 2016 Nov 10. PubMed PMID: 27840193.
12: Wu H, Liu H, Bai J, Lu Y, Du S. Simultaneous determination of notoginsenoside R₁, ginsenoside Rg₁, ginsenoside Re and 20(S) protopanaxatriol in beagle dog plasma by ultra high performance liquid mass spectrometry after oral administration of a Panax notoginseng saponin preparation. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jan 1;974:42-7. doi: 10.1016/j.jchromb.2014.10.025. Epub 2014 Oct 27. PubMed PMID: 25463196.
13: Yamabe N, Kim YJ, Lee S, Cho EJ, Park SH, Ham J, Kim HY, Kang KS. Increase in antioxidant and anticancer effects of ginsenoside Re-lysine mixture by Maillard reaction. Food Chem. 2013 Jun 1;138(2-3):876-83. doi: 10.1016/j.foodchem.2012.12.004. Epub 2012 Dec 8. PubMed PMID: 23411191.
14: Gao Y, Yang MF, Su YP, Jiang HM, You XJ, Yang YJ, Zhang HL. Ginsenoside Re reduces insulin resistance through activation of PPAR-γ pathway and inhibition of TNF-α production. J Ethnopharmacol. 2013 May 20;147(2):509-16. doi: 10.1016/j.jep.2013.03.057. Epub 2013 Mar 30. PubMed PMID: 23545455.
15: Kim U, Park MH, Kim DH, Yoo HH. Metabolite profiling of ginsenoside Re in rat urine and faeces after oral administration. Food Chem. 2013 Feb 15;136(3-4):1364-9. doi: 10.1016/j.foodchem.2012.09.050. Epub 2012 Sep 21. PubMed PMID: 23194536.
16: Hong NR, Park HS, Ahn TS, Kim HJ, Ha KT, Kim BJ. Ginsenoside Re inhibits pacemaker potentials via adenosine triphosphate-sensitive potassium channels and the cyclic guanosine monophosphate/nitric oxide-dependent pathway in cultured interstitial cells of Cajal from mouse small intestine. J Ginseng Res. 2015 Oct;39(4):314-21. doi: 10.1016/j.jgr.2015.02.004. Epub 2015 Mar 6. PubMed PMID: 26869823; PubMed Central PMCID: PMC4593795.
17: Liu J, Guo WF, Ren L, Chen WW. [Effects of ginsenoside Re on glucose absorption in Caco-2 cells]. Zhong Yao Cai. 2013 Dec;36(12):1992-5. Chinese. PubMed PMID: 25090688.
18: Su F, Xue Y, Wang Y, Zhang L, Chen W, Hu S. Protective effect of ginsenosides Rg1 and Re on lipopolysaccharide-induced sepsis by competitive binding to Toll-like receptor 4. Antimicrob Agents Chemother. 2015 Sep;59(9):5654-63. doi: 10.1128/AAC.01381-15. Epub 2015 Jul 6. PubMed PMID: 26149990; PubMed Central PMCID: PMC4538534.
19: Kim HM, Kim DH, Han HJ, Park CM, Ganipisetti SR, Valan Arasu M, Kim YO, Park CG, Kim BY, Soung NK. Ginsenoside Re Promotes Osteoblast Differentiation in Mouse Osteoblast Precursor MC3T3-E1 Cells and a Zebrafish Model. Molecules. 2016 Dec 29;22(1). pii: E42. doi: 10.3390/molecules22010042. PubMed PMID: 28036069.
20: Xiong Y, Chen D, Lv B, Liu F, Yao Q, Tang Z, Lin Y. Effects of ginsenoside Re on rat jejunal contractility. J Nat Med. 2014 Jul;68(3):530-8. PubMed PMID: 24658813.
